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437627

Sigma-Aldrich

Lipopolysaccharide, E. coli O111: B4

from E. coli, , lyophilized, iNOS stimulator, Calbiochem®

Synonyme(s) :

E. coli Lipopolysaccharide, E. coli O111:B4 LPS

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About This Item

Code UNSPSC :
12352201
Nomenclature NACRES :
NA.77

product name

Lipopolysaccharide, E. coli O111: B4, Lipopolysaccharide, E. coli O111: B4 stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes

Niveau de qualité

100

Forme

lyophilized

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze

Impuretés

≤2.0% Protein
≤2.5% nucleic acid

Conditions d'expédition

ambient

Température de stockage

2-8°C

Description générale

Endotoxin lipopolysaccharides initiate a variety of biochemical cell activation pathways (PKC, cAMP-dependent protein kinase, arachidonate metabolism, protein myristoylation, and activation of G-proteins). These unique macromolecules have been extensively studied in order to elucidate and define relevant pathophysiological parameters of endotoxic shock, a profound life-threatening consequence of sepsis. More recently, these bacterial products have generated intense interest due to their pluropotential immunostimulatory activity as manifested by the activation of host cells (e.g. B lymphocytes, macrophages) to functional differentiation. Host cell activation by lipopolysaccharides produces a spectrum of hormone-active lymphokines and monokines, including interferons (α, β, and γ), interleukins (IL-1 and IL-6), tumor necrosis factor, platelet activating factor, and procoagulant tissue factor. Stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.
Stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.

Actions biochimiques/physiologiques

Cell permeable: no
Primary Target
Inducible nitric oxide synthase
Product does not compete with ATP.
Reversible: no

Avertissement

Toxicity: Harmful (C)

Notes préparatoires

To achieve complete solubilization, heating solution to 37°C with intermittent vortexing or sonication may be necessary.

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Autres remarques

Hattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
Norimatsu, M., et al. 1995. Infect. Immun.63, 1122.
Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
Zhang, Y.H., et al. 1993. Infect. Immun.61, 5044.
Jackson, S.K., et al. 1992. Biochim. Biophys. Acta1135, 165.
O′Sullivan, M.G., et al. 1992. J. Biol. Chem.267, 14547.
Watanabe, K., et al. 1992. J. Cell. Physiol.150, 433.
Morrison, D.C., and Ryan, J.L. 1987. Annu. Rev. Med.38, 417.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H300

Classification des risques

Acute Tox. 2 Oral

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Zhan Zhao et al.
Journal of neuroinflammation, 17(1), 64-64 (2020-02-20)
Sepsis-associated acute brain inflammation, if unresolved, may cause chronic neuroinflammation and resultant neurodegenerative diseases. However, little is known how the transition from acute to chronic neuroinflammation, which is critical for the following progressive neurodegeneration, occurs in sepsis. The goal of

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