324895
eIF-2α Inhibitor, Salubrinal
eIF-2α Inhibitor, Salubrinal, CAS 304475-63-6, is a cell-permeable, selective inhibitor of the phosphatase complexes that dephosphorylate eIF-2α. Protects cells against ER stress-induced apoptosis.
Synonyme(s) :
eIF-2α Inhibitor, Salubrinal, Sal
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About This Item
Formule empirique (notation de Hill):
C21H17Cl3N4OS
Numéro CAS:
Poids moléculaire :
479.81
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77
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Niveau de qualité
Essai
≥90% (HPLC)
Forme
solid
Fabricant/nom de marque
Calbiochem®
Conditions de stockage
OK to freeze
protect from light
Couleur
beige
Solubilité
DMSO: 10 mg/mL
Conditions d'expédition
wet ice
Température de stockage
−20°C
Description générale
A cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to offer protection against ER stress-induced apoptosis (EC50 ~15 µM in PC12 cells stimulated with 750 ng/ml of Tunicamycin (Cat. No. 654380). Prevents HSV replication both in Vero cells (IC50 ~3 µM for reducing plaque formation) in vitro and in a mouse cornea infection model in vivo.
Actions biochimiques/physiologiques
Cell permeable: yes
Primary Target
elF-2α
elF-2α
Product does not compete with ATP.
Reversible: no
Target IC50: 3 µM preventing HSV replication both in Vero cells.
Conditionnement
Packaged under inert gas
Avertissement
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Autres remarques
Boyce, M., et al. 2005. Science307, 935.
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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