233183

Clodronate, Disodium Salt

A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption.

• Synonyme(s) : Clodronate, Disodium Salt, Clodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate
• Formule empirique (notation de Hill): CH₂Cl₂Na₂O₆P₂ · 4H₂O
• Numéro CAS: 88416-50-6
• Poids moléculaire : 360.92
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥97% (titration)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Couleur: white
• Solubilité: water: 1 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• InChI: 1S/CH4Cl2O6P2.2Na.4H2O/c2-1(3,10(4,5)6)11(7,8)9;;;;;;/h(H2,4,5,6)(H2,7,8,9);;;4*1H2/q;2*+1;;;;/p-2
• Clé InChI: XWHPUCFOTRBMGS-UHFFFAOYSA-L

Description

Description générale

A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. It is metabolized into a non-hydrolyzable ATP analog in osteoclasts and macrophages, and induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion, and migration of PC-3 prostate cancer cells (IC₅₀ = 100 nM).

A non-amino, chloro-containing, bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. Metabolized to a non-hydrolyzable ATP analog in osteoclasts and macrophages that induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion and migration of PC-3 prostate cancer cells (IC₅₀ = 100 nM).

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Osteoclast-mediated bone resorption

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 100 nM inhibiting invasion, adhesion, and migration of PC-3 prostate cancer cells

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Lehenkari, P.P., et al. 2002. Mol. Pharmacol.61, 1255.
Virtanen, S.S., et al. 2002. Cancer Res.62, 2708.
Smith, R., et al. 1971. Lancet1, 945.
Fleisch, H., et al. 1969. Nature223, 211.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable