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SML1074

Sigma-Aldrich

R1530

≥98% (HPLC)

Synonym(s):

5-(2-Chlorophenyl)-7-fluoro-1,2-dihydro-8-methoxy-3-methyl-pyrazolo[3,4-b][1,4]benzodiazepine

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About This Item

Empirical Formula (Hill Notation):
C18H14ClFN4O
CAS Number:
882531-87-5
Molecular Weight:
356.78
MDL number:
MFCD23704870
UNSPSC Code:
12352200
PubChem Substance ID:
329825456

Assay

≥98% (HPLC)

form

powder

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

color

, white to yellow to light brown

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

ClC1=CC=CC=C1C2=NC3=C(C)NN=C3NC4=C2C=C(F)C(OC)=C4

InChI

1S/C18H14ClFN4O/c1-9-16-18(24-23-9)21-14-8-15(25-2)13(20)7-11(14)17(22-16)10-5-3-4-6-12(10)19/h3-8H,1-2H3,(H2,21,23,24)

InChI key

UOVCGJXDGOGOCZ-UHFFFAOYSA-N

Gene Information

human ... AURKA(6790) , FGFR1(2260) , FGFR2(2263) , FLT1(2321) , FLT3(2322) , FLT4(2324) , KDR(3791) , PDGFRB(5159) , PLK4(10733)

Biochem/physiol Actions

R1530 is a multi-kinase inhibitor and an anti tumor agent.
R1530 is a multi-kinase inhibitor with activity against several kinases associated with tumor growth and angiogenesis, including VEGFR, FGFR, PDGFR, Chk2 and Cdk2. In tumor cells, R1530 inhibits tubulin polyerization and mitotic checkpoint function, resulting in polyploidy. The compound R1530 inhibits tumor growth and angiogenesis in animal models.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
074M4734V

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Amreena Suri et al.
International journal of molecular sciences, 20(9) (2019-05-01)
Polo-like kinase 4 (PLK4) is a cell cycle-regulated protein kinase (PK) recruited at the centrosome in dividing cells. Its overexpression triggers centrosome amplification, which is associated with genetic instability and carcinogenesis. In previous work, we established that PLK4 is overexpressed
Tomas Vanek et al.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 50(11), 1148-1159 (2015-07-21)
Performance of a two-stage biofiltration system was investigated for removal of styrene-acetone mixtures. High steady-state acetone loadings (above C(in)(Ac) = 0.5 g.m(-3) corresponding to the loadings > 34.5 g.m(-3).h(-1)) resulted in a significant inhibition of the system's performance in both

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