P183
(+)-PD 128,907 hydrochloride
>97%, solid
Synonym(s):
(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C14H19NO3 · HCl
CAS Number:
Molecular Weight:
285.77
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Assay:
>97%
Form:
solid
assay
>97%
form
solid
color
off-white
solubility
ethanol: >10 mg/mL, DMSO: 18 mg/mL, H2O: 9 mg/mL
SMILES string
Cl.CCCN1CCO[C@H]2[C@H]1COc3ccc(O)cc23
InChI
1S/C14H19NO3.ClH/c1-2-5-15-6-7-17-14-11-8-10(16)3-4-13(11)18-9-12(14)15;/h3-4,8,12,14,16H,2,5-7,9H2,1H3;1H/t12-,14-;/m1./s1
InChI key
DCFXOTRONMKUJB-QMDUSEKHSA-N
Gene Information
human ... DRD3(1814)
Biochem/physiol Actions
Selective D3 dopamine receptor agonist.
Legal Information
Manufactured and sold with the permission of Warner-Lambert Company.
Disclaimer
Light sensitive
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Assessment of cocaine-like discriminative stimulus effects of dopamine D3 receptor ligands.
Acri, et al.
European Journal of Pharmacology, 281 (1995)
F Sautel et al.
Neuroreport, 6(2), 329-332 (1995-01-26)
The functional potency of a series of dopamine agonists for increasing mitogenesis, measured by incorporation of [3H]thymidine, was established in transfected cell lines expressing human D2 or D3 receptors. The functional selectivity of agonists markedly differs from their binding selectivity.
H A DeWald et al.
Journal of medicinal chemistry, 33(1), 445-450 (1990-01-01)
The dopamine agonist profile of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol (16a) and its enantiomers (16b-c) was examined. Racemic 16a exhibited moderate affinity for the dopamine (DA) D2 receptor labeled with the DA antagonist ligand [3H]haloperidol and moderate in vivo activity; it attenuated gamma-butyrolactone-stimulated
Global Trade Item Number
| SKU | GTIN |
|---|---|
| P183-25MG | 04061832272894 |
| P183-5MG | 04061832092560 |