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P148

4α-Phorbol 12-myristate 13-acetate

solid, ≥95% (TLC)

Synonym(s):

4α-PMA

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Pack SizeSKUAvailabilityPrice
1 mg
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€ 230,00

About This Item

Empirical Formula (Hill Notation):
C36H56O8
CAS Number:
63597-44-4
Molecular Weight:
616.83
NACRES:
NA.77
PubChem Substance ID:
24898203
UNSPSC Code:
12352211
MDL number:
MFCD00153860
Assay:
≥95% (TLC)
Form:
solid
Quality level:
100

€ 230,00

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Quality Level

100

assay

≥95% (TLC)

form

solid

color

white

solubility

H2O: ~2 μM, DMSO: soluble, ethanol: soluble

storage temp.

−20°C

SMILES string

CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(C)=O

InChI

1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34+,35-,36-/m1/s1

InChI key

PHEDXBVPIONUQT-LQLWEASQSA-N

General description

Though having aqueous solubility, it is recommended that this compound first be dissolved in a water miscible organic solvent before dilution to working concentrations in aqueous media.

Biochem/physiol Actions

Negative control for phorbol ester activation of protein kinase C.

Packaging

Sealed glass ampule.

Disclaimer

Photosensitive

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This Item
P8139P8014P1269
4α-Phorbol 12-myristate 13-acetate solid, ≥95% (TLC)

Sigma-Aldrich

P148

4α-Phorbol 12-myristate 13-acetate

Phorbol 12-myristate 13-acetate ≥99% (TLC), film or powder

Sigma-Aldrich

P8139

Phorbol 12-myristate 13-acetate

4α-Phorbol 12,13-didecanoate solid

Sigma-Aldrich

P8014

4α-Phorbol 12,13-didecanoate

Phorbol 12,13-dibutyrate ≥98% (TLC), powder

Sigma-Aldrich

P1269

Phorbol 12,13-dibutyrate

form

solid

form

film or powder

form

solid

form

powder

assay

≥95% (TLC)

assay

≥99% (TLC)

assay

-

assay

≥98% (TLC)

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

H2O: ~2 μM, ethanol: soluble, DMSO: soluble

solubility

DMSO: soluble, ethanol: soluble (Dissolve in water-miscible organic solvent prior to preparing aqueous solutions.)

solubility

DMSO: soluble, ethanol: soluble, methanol: soluble

solubility

H2O: 30 μM, DMSO: soluble, acetone: soluble, ethanol: soluble

color

white

color

-

color

white

color

clear light yellow

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCR3206
MKCQ1294
MKCN8591
MKCL0558
MKCG5400

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Shirley A Cotton et al.
Kidney international, 61(1), 61-67 (2002-01-12)
Significant variability exists in the outcome of renal parenchymal inflammation following urinary tract infection (UTI) in childhood as some children experience renal parenchymal scarring (RPS) while others do not scar. Since TGF-beta1 is pro-fibrotic, we examined the role of this
S M Fischer et al.
Cancer research, 51(3), 850-856 (1991-02-01)
There is substantial evidence that the tumor promoter 4 beta-12-O-tetradecanoylphorbol-13-acetate (TPA) elicits enhanced arachidonic acid release and its metabolism to prostaglandins and lipoxygenase products in many cell types. The goal of this study was to determine whether 4 alpha-12-O-tetradecanoylphorbol-13-acetate (4
B L Van Duuren et al.
Cancer research, 39(7 Pt 1), 2644-2646 (1979-07-01)
4a alpha-Phorbol-9,9a-didecanoate, 4a alpha-phorbol-9-myristate-9a-acetate, and phorbol-9-myristate-9a-acetate-3-aldehyde were tested for skin tumor-promoting activity by using 7,12-dimethylbenz(a)anthracene as the initiating agent. There were 30 female ICR/Ha mice/group, and tests were continued for 434 to 461 days. 4a alpha-Phorbol-9,9a-didecanoate and 4a alpha-phorbol-9-myristate-9a-acetate were
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Global Trade Item Number

SKUGTIN
P148-1MG04061834355052

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