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F8180

FMS (539-end), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

C-FMS, CD115, CSF1R, CSFR, FIM2

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About This Item

NACRES:
NA.32
UNSPSC Code:
12352200
Specific activity:
18-24 nmol/min·mg
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

18-24 nmol/min·mg

mol wt

~76 kDa

UniProt accession no.

P07333

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CSF1R(1436)

General description

FMS, also called CSF1R colony stimulating factor 1 receptor, acts as a receptor for CSF1, and they both as key regulators of monocyte and macrophage functioning.[1] It is a member of the platelet-derived growth factor (PDGF) family of proteins, and is a type III RTK (receptor tyrosine kinase). It is composed of five immunoglobulin (Ig)-like domains, a transmembrane region, a juxtamembrane domain, and kinase insert domain (KID) intersecting the kinase domain.[2]

Biochem/physiol Actions

FMS also called CSF1R colony stimulating factor 1 receptor, and its ligand CSF1 are linked to poor prognosis in patients with solid tumors, and in patients with female reproductive cancers. In breast cancers with decreased claudin levels, this protein regulates the switch between proliferative and invasive state of the tumor, acting downstream of TGFβ (tumor growth factor β).[3] Haploinsufficiency in this receptor might lead to aberration of microglial function, which might be a contributor to the pathogenesis of hereditary diffuse leukoencephalopathy with spheroids (HDLS).[4][2]

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

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SAB5700581SAB2501384G8671
FMS (539-end), active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

F8180

FMS (539-end), active, GST tagged human

Anti-Phospho-CSF1R-Y723 antibody produced in rabbit

Sigma-Aldrich

SAB5700581

Anti-Phospho-CSF1R-Y723 antibody produced in rabbit

Anti-CSF1R antibody produced in goat affinity isolated antibody, buffered aqueous solution

Sigma-Aldrich

SAB2501384

Anti-CSF1R antibody produced in goat

PDGFRβ(557-end), active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

G8671

PDGFRβ(557-end), active, GST tagged human

specific activity

18-24 nmol/min·mg

specific activity

-

specific activity

-

specific activity

16-22 nmol/min·mg

Gene Information

human ... CSF1R(1436)

Gene Information

human ... CSF1R(1436)

Gene Information

human ... CSF1R(1436)

Gene Information

human ... PDGFRB(5159)

assay

≥70% (SDS-PAGE)

assay

-

assay

-

assay

≥70% (SDS-PAGE)

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

-

recombinant

-

recombinant

expressed in baculovirus infected Sf9 cells

form

buffered aqueous glycerol solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous glycerol solution

mol wt

~76 kDa

mol wt

107, 33

mol wt

-

mol wt

~104 kDa

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLCP9056
SLCJ4324

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C J Sherr
International journal of cell cloning, 8 Suppl 1, 46-60 (1990-01-01)
Colony-stimulating factor-1 (CSF-1 or M-CSF) regulates pleiotropic developmental and functional responses of macrophages and their committed bone marrow progenitors and supports the viability of cells of the mononuclear phagocyte lineage. Its actions are mediated through its binding to cell surface
George Alexander Follows et al.
Oncogene, 24(22), 3643-3651 (2005-04-05)
The macrophage colony-stimulating factor receptor is encoded by the c-FMS gene, and it has been suggested that altered regulation of c-FMS expression may contribute to leukaemic transformation. c-FMS is expressed in pluripotent haemopoietic precursor cells and is subsequently upregulated during
Takuya Konno et al.
Neurology, 82(2), 139-148 (2013-12-18)
To clarify the genetic, clinicopathologic, and neuroimaging characteristics of patients with hereditary diffuse leukoencephalopathy with spheroids (HDLS) with the colony stimulating factor 1 receptor (CSF-1R) mutation. We performed molecular genetic analysis of CSF-1R in patients with HDLS. Detailed clinical and
View All Related Papers

Global Trade Item Number

SKUGTIN
F8180-10UG04061837753725

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