The solubility and solution stability of this product have not been determined. However, online sources report that this material is soluble in DMSO and Ethanol at >50 mg/mL. Anhydrous solvents are recommended. Stock solutions may be stored up to 1 month at -20°C for 1 year at -80°C. This information has not been validated.
C6492
Ciproxifan hydrochloride
≥98% (HPLC), solid
Synonym(s):
Cyclopropyl[4-[3-(1H-imidazol-4-yl)propoxyl]phenyl]-methanone hydrochloride
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | € 187,00 |
25 mg | Check Cart for Availability | € 533,00 |
About This Item
Empirical Formula (Hill Notation):
C16H18N2O2 · HCl
CAS Number:
Molecular Weight:
306.79
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
desiccated, under inert gas
Quality Segment
assay
≥98% (HPLC)
form
solid
storage condition
desiccated, under inert gas
color
off-white
solubility
DMSO: 30 mg/mL, water, high purity: 30 mg/mL
storage temp.
2-8°C
SMILES string
Cl.O=C(C1CC1)c2ccc(OCCCc3c[nH]cn3)cc2
InChI
1S/C16H18N2O2.ClH/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14;/h5-8,10-12H,1-4,9H2,(H,17,18);1H
InChI key
PWAPSKMHZQQTRJ-UHFFFAOYSA-N
Biochem/physiol Actions
Ciproxifan belongs to a novel chemical series of histamine H3-receptor antagonists. In vitro, it behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. Ciproxifan appears to be an orally bioavailable, extremely potent and selective H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.
H3 histamine receptor antagonist.
Features and Benefits
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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This Item | |||
|---|---|---|---|
| form solid | form powder | form powder | form - |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 30 mg/mL, water, high purity: 30 mg/mL | solubility DMSO: 32 mg/mL, H2O: insoluble | solubility H2O: 2 mg/mL, clear | solubility H2O: 30 mg/mL, clear |
| storage condition desiccated, under inert gas | storage condition - | storage condition desiccated | storage condition desiccated |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Can I store aliquots in -80 °C after diluting it in water?
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