C5608

Collagen from rabbit skin

Bornstein and Traub Type I, powder

• CAS Number: 9007-34-5
• UNSPSC Code: 12352202
• EC Number: 232-697-4
• NACRES: NA.61
• MDL number: MFCD00130825
• Form: powder
• Biological source: rabbit skin

Properties

• biological source: rabbit skin
• Quality Segment: 200
• description: acid soluble
• form: powder
• technique(s): cell culture | stem cell: suitable
• solubility: aqueous acid: ≤10 mg/mL, aqueous sodium acetate buffer: soluble (0.01-0.5M)
• UniProt accession no.: Q28668
• storage temp.: 2-8°C
• Gene Information: rabbit ... COL1A2(100008997)

Description

General description

Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.

Application

Collagen-type 1 may be used in research of Idiopathic pulmonary fibrosis (IPF). Robust expression of collagen-type 1 is one distinctive feature of IPF. Additionally, collagen-type 1 has been used in studies on the effect of endoplasmic reticulum (ER) stress from IPF on myofibroblastic differentiation of lung fibroblasts. Collage-type 1 soluble in acidic solution produces three dimensional scaffolding useful in bioengineering and cell culture applications where biomaterials are needed to replace native collagen extracellular matrices.

Collagen Type I has been used as a scaffold for the growth in vitro of stem cells in a wide variety of biomaterial engineering studies.

Preparation Note

Prepared with modification of Gallop, P.M.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)