C199

CGS-15943

≥98% (HPLC), Adenosine receptor antagonist, solid

• Synonym(s): 9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
• Empirical Formula (Hill Notation): C₁₃H₈ClN₅O
• CAS Number: 104615-18-1
• Molecular Weight: 285.69
• UNSPSC Code: 12352202
• PubChem Substance ID: 24277704
• NACRES: NA.77
• MDL number: MFCD01529897
• Assay: ≥98% (HPLC)
• Form: solid

Properties

• Product Name: CGS-15943, solid
• assay: ≥98% (HPLC)
• Quality Segment: 100
• form: solid
• color: white
• solubility: DMSO: >10 mg/mL, H₂O: insoluble
• storage temp.: room temp
• SMILES string: Nc1nc2ccc(Cl)cc2c3nc(nn13)-c4ccco4
• InChI: 1S/C13H8ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16)
• InChI key: MSJODEOZODDVGW-UHFFFAOYSA-N
• Gene Information: human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140) ; rat ... Adora1(29290), Adora2a(25369), Adora2b(29316)

Description

Application

CGS-15943 has been used as a non-selective adenosine receptor antagonist to study its effects on the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and hepatocellular carcinoma (HCC)[1]. It has also been used as a non-selective adenosine receptor antagonist to investigate the mechanism underlying adenosine inhibition on cholangiocarcinoma (CCA) cells.[2]

Biochem/physiol Actions

CGS-15943 is a potent and non-selective adenosine receptor antagonist. It exhibits anti-carcinogenic and anti-apoptotic activity.[1]

Safety Information

• ppe: Eyeshields, Gloves, type N95 (US)
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable