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B3436

N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide

≥98% (HPLC), solid

Synonym(s):

C2-8

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Size/SKUAvailabilityPrice
25 mg
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€ 618,00

About This Item

Empirical Formula (Hill Notation):
C19H14Br2N2O3S
CAS Number:
300670-16-0
Molecular Weight:
510.20
NACRES:
NA.77
PubChem Substance ID:
24724418
UNSPSC Code:
12352200
MDL number:
MFCD00355835
Assay:
≥98% (HPLC)
Form:
solid

€ 618,00

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Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: ~20 mg/mL, H2O: insoluble

storage temp.

2-8°C

SMILES string

Brc1ccc(NC(=O)c2cccc(c2)S(=O)(=O)Nc3ccc(Br)cc3)cc1

InChI

1S/C19H14Br2N2O3S/c20-14-4-8-16(9-5-14)22-19(24)13-2-1-3-18(12-13)27(25,26)23-17-10-6-15(21)7-11-17/h1-12,23H,(H,22,24)

InChI key

SJJKUNDBFWUAQB-UHFFFAOYSA-N

Biochem/physiol Actions

N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl] benzamide is the first inhibitor of aggregation of the polyglutamine (polyQ) sequence of the Huntington′s Disease protein (huntingtin).
N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide is the first inhibitor of aggregation of the polyglutamine (polyQ) sequence of the Huntington′s Disease protein (huntingtin); polyQ aggregation is neurotoxic, and inhibitors of aggregation may be therapeutic in HD and other polyQ diseases; C2-8 inhibited aggregation in HD PC12 cells with an IC50 of 50nM; when administered in food, suppressed neurodegeneration in vivo in the Drosophila HD model.

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This Item
P0618S4443C3118
N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide ≥98% (HPLC), solid

Sigma-Aldrich

B3436

N-(4-Bromophenyl)-3-[[(4-bromophenyl)amino]sulfonyl]benzamide

cis-8-Hydroxy-3-(n-propyl)-1,2,3a,4,5,9b-hexahydro-1H-benz[e]indole hydrobromide ≥98% (HPLC), solid

Sigma-Aldrich

P0618

cis-8-Hydroxy-3-(n-propyl)-1,2,3a,4,5,9b-hexahydro-1H-benz[e]indole hydrobromide

SCH-28080 ≥98% (HPLC), solid

Sigma-Aldrich

S4443

SCH-28080

CPNQ ≥98% (HPLC), solid

Sigma-Aldrich

C3118

CPNQ

form

solid

form

solid

form

solid

form

solid

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: ~20 mg/mL, H2O: insoluble

solubility

H2O: soluble ~10 mg/mL at 60 °C (Sonicate), DMSO: soluble 12 mg/mL

solubility

DMSO: soluble >10 mg/mL, H2O: insoluble

solubility

H2O: insoluble <2 mg/mL, DMSO: >5 mg/mL

color

off-white

color

light brown

color

white to light tan

color

brown

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319,H413

Hazard Classifications

Aquatic Chronic 4 - Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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