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DL-2-Amino-5-phosphonovaleric acid lithium salt

Name: <SC>DL</SC>-2-Amino-5-phosphonovaleric acid lithium salt
Brand: SIGMA

~95%

Synonym(s):

DL-2-Amino-5-phosphonopentanoic acid, AP-5

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About This Item

Linear Formula:

C₅H₁₁NO₅PLi

CAS Number:

125229-62-1

Molecular Weight:

203.06

NACRES:

NA.26

PubChem Substance ID:

24891104

UNSPSC Code:

12352106

MDL number:

MFCD00078901

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Properties

assay

~95%

Quality Level

100

form

powder

technique(s)

ligand binding assay: suitable

color

white to off-white

SMILES string

[Li].NC(CCCP(O)(O)=O)C(O)=O

InChI

1S/C5H12NO5P.Li.H/c6-4(5(7)8)2-1-3-12(9,10)11;;/h4H,1-3,6H2,(H,7,8)(H2,9,10,11);;

InChI key

QIVHTKSFMZBERS-UHFFFAOYSA-N

Gene Information

rat ... Grik1(29559), Grin2a(24409), Grin2b(24410)

Description

Biochem/physiol Actions

Anticonvulsant; potent and selective antagonist for NMDA receptors.

DL-2-Amino-5-phosphonovaleric acid is a selective N-methyl-d-aspartate (NMDA) receptor antagonist used frequently in studies of neurological processes

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This Item	A8054	A3785	A7502
Sigma-Aldrich A6553 DL-2-Amino-5-phosphonovaleric acid lithium salt	Sigma-Aldrich A8054 D(−)-2-Amino-5-phosphonopentanoic acid	Sigma-Aldrich A3785 5-Aminolevulinic acid hydrochloride	Sigma-Aldrich A7502 DL-Alanine
form powder	form powder	form powder	form powder
technique(s) ligand binding assay: suitable	technique(s) ligand binding assay: suitable	technique(s) ligand binding assay: suitable	technique(s) ligand binding assay: suitable
assay ~95%	assay ≥98% (TLC)	assay ≥98%	assay ≥99% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 300	Quality Level 200
color white to off-white	color white	color -	color white to off-white
Gene Information rat ... Grik1(29559), Grin2a(24409), Grin2b(24410)	Gene Information mouse ... Grin2a(14811) rat ... Grik1(29559), Grin2a(24409), Grin2b(24410), Grin2c(24411), Grin2d(24412)	Gene Information -	Gene Information -

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Nicotine ameliorates NMDA receptor antagonist-induced deficits in contextual fear conditioning through high-affinity nicotinic acetylcholine receptors in the hippocampus.

Jessica M André et al.

Neuropharmacology, 60(4), 617-625 (2010-12-21)

NMDA glutamate receptors (NMDARs) and nicotinic acetylcholine receptors (nAChRs) are both involved in learning and synaptic plasticity. Increasing evidence suggests processes mediated by these receptors may interact to modulate learning; however, little is known about the neural substrates involved in

Pre-synaptic histamine H₃ receptors modulate glutamatergic transmission in rat globus pallidus.

A Osorio-Espinoza et al.

Neuroscience, 176, 20-31 (2011-01-05)

The globus pallidus, a neuronal nucleus involved in the control of motor behavior, expresses high levels of histamine H(3) receptors (H(3)Rs) most likely located on the synaptic afferents to the nucleus. In this work we studied the effect of the

Differential long-term depression in CA3 but not in dentate gyrus following low-frequency stimulation of the medial perforant path.

Thomas K Fung et al.

Synapse (New York, N.Y.), 65(7), 677-686 (2010-12-31)

Synaptic plasticity may depend not only on the afferent fibers but also on the recipient structure. The medial perforant path (MPP) from the entorhinalcortex projects to both the dentate gyrus (DG) and CA3, resulting in excitatory postsynaptic potentials (EPSPs) in

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Global Trade Item Number

SKU	GTIN
A6553-25MG	04061833382462
A6553-10MG	04061832415024

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DL-2-Amino-5-phosphonovaleric acid lithium salt

~95%

Select a Size

About This Item

assay

Quality Level

form

technique(s)

color

SMILES string

InChI

InChI key

Gene Information

Biochem/physiol Actions

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Storage Class

wgk

flash_point_f

flash_point_c

ppe

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