45245
Eosin 5-isothiocyanate
≥95.0% (UV)
Synonym(s):
EITC
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About This Item
Empirical Formula (Hill Notation):
C21H7Br4NO5S
CAS Number:
Molecular Weight:
704.96
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
≥95.0% (UV)
fluorescence
λex 521; λem 544 (pH 9.0)
storage temp.
2-8°C
SMILES string
OC(=O)c1cc(ccc1C2=C3C=C(Br)C(=O)C(Br)=C3Oc4c(Br)c(O)c(Br)cc24)N=C=S
InChI
1S/C21H7Br4NO5S/c22-12-4-10-14(8-2-1-7(26-6-32)3-9(8)21(29)30)11-5-13(23)18(28)16(25)20(11)31-19(10)15(24)17(12)27/h1-5,27H,(H,29,30)
InChI key
MCXYFYWNOWPDMA-UHFFFAOYSA-N
Application
Eosin 5-isothiocyanate (EITC) is a fluorescence probe. EITC tagged molecules may be used together with fluorescein-5′-isothiocyanate (FITC) tagged molecules in fluoresce resonance energy transfer (FRET) based assays.
signalword
Danger
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
flash_point_f
Not applicable
hcodes
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Articles
Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.
T Chiba et al.
Biochimica et biophysica acta, 897(1), 14-24 (1987-02-12)
The characteristics of the anion transport system in human erythrocyte, which can be modified by eosin 5-isothiocyanate (EITC), were studied using the pH titration method and by measuring the sulfate efflux. Based on the pH dependence of EITC binding to
S Q Liu et al.
The American journal of physiology, 264(5 Pt 1), C1155-C1164 (1993-05-01)
Although eosin-5-maleimide (EM) covalently labels band 3 and has been thought to react at the external-facing anion transport site, EM reversibly inhibits Cl- exchange at 0 degrees C in a noncompetitive fashion, indicating that under these conditions it does not
Valeria Levi et al.
Biochimica et biophysica acta, 1599(1-2), 141-148 (2002-12-14)
Self-association of bovine serum albumin (BSA) was explored using fluorescence resonance energy transfer (FRET) between two populations of the protein labeled separately with either fluorescein-5'-isothiocyanate (FITC) or eosin-5'-isothiocyanate (EITC). The energy transfer reached the steady state after 5 s at