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D1065

4-(2-[6-(Dioctylamino)-2-naphthalenyl]ethenyl)-1-(3-sulfopropyl)pyridinium inner salt

≥95% purity (HPLC), solid

Synonym(s):

Di-8-ANEPPS

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5 mg
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€ 760,00

About This Item

Empirical Formula (Hill Notation):
C36H52N2O3S
CAS Number:
Molecular Weight:
592.87
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47
MDL number:

€ 760,00


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Product Name

4-(2-[6-(Dioctylamino)-2-naphthalenyl]ethenyl)-1-(3-sulfopropyl)pyridinium inner salt, ≥95% (HPLC), solid

Quality Segment

assay

≥95% (HPLC)

form

solid

mol wt

592.88

color

orange to red

solubility

DMSO: soluble, ethanol: soluble

ε (extinction coefficient)

≥37 at 495-501  nm in methanol

fluorescence

λex 710-716 nm

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

2-8°C

SMILES string

CCCCCCCCN(CCCCCCCC)c1ccc2cc(\C=C\c3cc[n+](CCCS([O-])(=O)=O)cc3)ccc2c1

InChI

1S/C36H52N2O3S/c1-3-5-7-9-11-13-25-38(26-14-12-10-8-6-4-2)36-21-20-34-30-33(18-19-35(34)31-36)17-16-32-22-27-37(28-23-32)24-15-29-42(39,40)41/h16-23,27-28,30-31H,3-15,24-26,29H2,1-2H3

InChI key

IXFSUSNUALIXLU-UHFFFAOYSA-N

Biochem/physiol Actions

Fast-responding membrane potential dye.

Other Notes

More suitable for long-term membrane potential studies than di-4-ANEPPS (Cat. No. D8064) because of better retention in the outer leaflet of plasma membranes.


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Carlos A Valverde et al.
Cardiovascular research, 115(3), 556-569 (2018-09-01)
Abnormal Ca2+ release from the sarcoplasmic reticulum (SR), associated with Ca2+-calmodulin kinase II (CaMKII)-dependent phosphorylation of RyR2 at Ser2814, has consistently been linked to arrhythmogenesis and ischaemia/reperfusion (I/R)-induced cell death. In contrast, the role played by SR Ca2+ uptake under
Antonio Celestino-Montes et al.
Life sciences, 264, 118700-118700 (2020-11-02)
Ventricular myocytes (VM) depolarization activates L-type Ca2+ channels (LCC) allowing Ca2+ influx (ICa) to synchronize sarcoplasmic reticulum (SR) Ca2+ release, via Ca2+-release channels (RyR2). The resulting whole-cell Ca2+ transient triggers contraction, while cytosolic Ca2+ removal by SR Ca2+ pump (SERCA2)
Sanaya N Shroff et al.
iScience, 23(4), 100974-100974 (2020-04-17)
Precise measurement of action potentials (APs) is needed to observe electrical activity and cellular communication within cardiac tissue. Voltage-sensitive dyes (VSDs) are traditionally used to measure cardiac APs; however, they require acute chemical addition that prevents chronic imaging. Genetically encoded



Global Trade Item Number

SKUGTIN
D1065-5MG04061832342351

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