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1255850

USP

Eszopiclon

United States Pharmacopeia (USP) Reference Standard

Synonym(e):

(+)-Eszopiclon, (S)-Zopiclon, 4-Methylpiperazin-1-carbonsäure-[(5S)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl]-ester

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Über diesen Artikel

Empirische Formel (Hill-System):
C17H17ClN6O3
CAS-Nummer:
Molekulargewicht:
388.81
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24
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grade

pharmaceutical primary standard

agency

USP

API family

eszopiclone

manufacturer/tradename

USP

drug control

USDEA Schedule IV

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Clc1cnc(cc1)N2[C@H](c4nccnc4C2=O)OC(=O)N3CCN(CC3)C

InChI

1S/C17H17ClN6O3/c1-22-6-8-23(9-7-22)17(26)27-16-14-13(19-4-5-20-14)15(25)24(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3/t16-/m0/s1

InChI key

GBBSUAFBMRNDJC-INIZCTEOSA-N

General description

Find answers to frequently asked questions on USP products in USP FAQs.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Eszopiclone USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Eszopiclone Tablets

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.


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Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2 - STOT SE 3

target_organs

Central nervous system

Lagerklasse

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable



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Questions

  1. Hi. What is the solubility of Eszopiclone in water and PBS?

    1 answer
    1. The solubility of this USP standard has not been determined. Various sources note that this material is soluble at 0.885 mg/mL in water. In addition, PBS at pH 3.2 and 0.01 M HCl are listed, with no concentration reported. Please see the links below to review additional information that may be helpful:
      https://pubs.acs.org/doi/10.1021/acs.jced.0c00047#
      https://go.drugbank.com/drugs/DB00402
      https://patents.google.com/patent/EP1997482A1/en

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