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Merck

1043003

USP

Ascorbinsäure

United States Pharmacopeia (USP) Reference Standard

Synonym(e):

L-Ascorbinsäure, L-Threoascorbinsäure, Anti-Scorbut-Faktor, Vitamin C

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Über diesen Artikel

Empirische Formel (Hill-System):
C6H8O6
CAS-Nummer:
Molekulargewicht:
176.12
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
200-066-2
Beilstein/REAXYS Number:
84272
MDL number:

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InChI

1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

SMILES string

OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O

InChI key

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

grade

pharmaceutical primary standard

API family

ascorbic acid

form

solid

manufacturer/tradename

USP

technique(s)

HPLC: suitable

mp

190-194 °C (dec.)

application(s)

USP Biologics
pharmaceutical (small molecule)

format

neat

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Dieser Artikel
A1300000A221857803
Ascorbic acid European Pharmacopoeia (EP) Reference Standard

A1300000

Ascorbic acid

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

-

grade

certified reference material, TraceCERT®

manufacturer/tradename

USP

manufacturer/tradename

EDQM

manufacturer/tradename

-

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

food and beverages

format

neat

format

neat

format

-

format

neat

API family

ascorbic acid

API family

ascorbic acid

API family

-

API family

-

technique(s)

HPLC: suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

General description

Ascorbic acid, commonly known as vitamin C, is a water-soluble vitamin with antioxidant properties. In pharmaceutical and food industries, ascorbic acid is used as an antioxidant to prevent oxidation and spoilage. The USP Ascorbic Acid standard ensures the quality and potency of ascorbic acid in various formulations.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

Application

Der USP-Referenzstandard Ascorbinsäure ist zur Verwendung für die in den USP-Kompendien spezifizierten Qualitätsprüfungen und Assays vorgesehen. Er dient auch zur Verwendung mit USP-Monografien wie:
  • Ascorbinsäure-Tabletten
  • Ascorbinsäure-Injektion
  • Ascorbinsäure-Kaugummi-Gele
  • Ascorbinsäure kombinierte Lösung zum Einnehmen
  • Natrium-Ascorbat
  • Calcium-Ascorbat

Analysis Note

Diese Produkte sind ausschließlich zur Verwendung in Tests und Assays vorgesehen. Sie sind nicht für die Verabreichung an Menschen oder Tiere bestimmt und dürfen nicht zur Diagnose, Behandlung oder Heilung von Krankheiten jeglicher Art verwendet werden.

Other Notes

Dieses Produkt ist Teil des USP-Biologics-Programms.
Ggf. sind Verkaufsbeschränkungen zu beachten.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Lagerklasse

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable


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Analysenzertifikate (COA)

Lot/Batch Number

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Die Dokumentenbibliothek aufrufen

Ascorbic Acid Chewable Gels
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(4), 4765-4765 (2019)
Ascorbic Acid Compounded Oral Solution
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(4), 2626-2626 (2020)
Glutathione
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 41(3), 5054-5054 (2020)
W Lee et al.
Clinical chemistry, 28(10), 2165-2169 (1982-10-01)
Measurements of ascorbic acid concentration in leukocytes by "high-performance" liquid chromatography (HPLC) provides better nutritional assessment, leading to better management, particularly of presymptomatic and critically ill patients. This procedure includes a simple, reproducible cell-separation technique that requires no more than
Preharvest and postharvest factors influencing vitamin C content of horticultural crops.
Lee, Seung K., and Adel A. Kader.
Postharvest biology and technology, 20.3, 207-220 (2000)

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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