Z0878

Zaprinast

cGMP-specific phosphodiesterases V and VI inhibitor, solid

• Synonym(e): 1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo(4,5-d)pyrimidin-7-one
• Empirische Formel (Hill-System): C₁₃H₁₃N₅O₂
• CAS-Nummer: 37762-06-4
• Molekulargewicht: 271.27
• NACRES: NA.77
• PubChem Substance ID: 24278072
• UNSPSC Code: 12352202
• EC Number: 253-655-1
• MDL number: MFCD00214073
• Form: solid

Eigenschaften

• Produktname: Zaprinast, solid
• form: solid
• Quality Segment: 200
• color: white
• solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.11 mg/mL, DMSO: 10 mg/mL, H₂O: insoluble
• SMILES string: CCCOc1ccccc1C2=NC(=O)c3nn[nH]c3N2
• InChI: 1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
• InChI key: REZGGXNDEMKIQB-UHFFFAOYSA-N
• Gene Information: human ... PDE2A(5138), PDE4A(5141), PDE4B(5142), PDE4D(5144)

Beschreibung

Application

Zaprinast has been used to determine its inhibitory effect on the meiosis of oocytes by germinal vesicle breakdown (GVBD) assay and to test the inhibitory effect of it on the retinal cells by immunohistochemistry.

Biochem/physiol Actions

Selective inhibitor of cGMP-specific phosphodiesterases V and VI (PDE5/6) and an agonist at the G protein-coupled receptor 35 (GPR35).

Zaprinast insubstantially inhibits phosphodiesterase 10 and 11 (PDE10 and PDE11). It also exhibits vasodilating effects.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves