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T7750
2-Thiouracil
≥99%, synthetic, powder
Synonym(e):
4-Hydroxy-2-mercapto-pyrimidin
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 25 g | Warenkorb auf Verfügbarkeit prüfen | € 43,20 | |
| 100 g | Warenkorb auf Verfügbarkeit prüfen | € 144,00 € 122,40 | |
| 250 g | Warenkorb auf Verfügbarkeit prüfen | € 283,00 € 240,55 | |
| 1 kg | Warenkorb auf Verfügbarkeit prüfen | € 886,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C4H4N2OS
CAS-Nummer:
Molekulargewicht:
128.15
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
205-508-8
MDL number:
Beilstein/REAXYS Number:
112227
Assay:
≥99%
Biological source:
synthetic
Form:
powder
Solubility:
1 M NaOH: 5 mg/mL, clear to very slightly hazy, 1 M NaOH: 50 mg/mL, colorless to faintly yellow
€ 43,20
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Unterstützung erhaltenProduktname
2-Thiouracil, ≥99%
biological source
synthetic
Quality Level
assay
≥99%
form
powder
mp
>300 °C (lit.)
solubility
1 M NaOH: 5 mg/mL, clear to very slightly hazy, 1 M NaOH: 50 mg/mL, colorless to faintly yellow
SMILES string
O=C1NC(=S)NC=C1
InChI
1S/C4H4N2OS/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)
InChI key
ZEMGGZBWXRYJHK-UHFFFAOYSA-N
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General description
2-Thiouracil is a thio-derivative of uracil, a pyrimidine nucleobase.This antithyroid drug has less solubility in H2O & organic solvents.
Application
2-Thiouracil may be used:
- in the synthesis and characterization of silver colloid and film substrates and their applications in surface-enhanced Raman scattering (SERS)
- to study its electro-oxidation and determination at titanium dioxide (TiO2) nanoparticles-modified gold electrode
- to study the effect of methylation on the deactivation mechanism or the triplet-state dynamics of 2-thiouracil using time-resolved photoelectron spectroscopy
Biochem/physiol Actions
2-Thiouracil acts as an anticancer, antithyroid, and antiviral agent. 2-Thiouracil is a selective melanoma-seeker and competitive inhibitor of neuronal nitric oxide synthase.[1] It also forms complexes with transition metals such as gold (Au), chromium (Cr), zinc (Zn), and silver (Ag).2-thiouracil can be incorporated into the tissue culture medium to inhibit virus replication or movement from infected to healthy tissues during chemotherapy.
signalword
Warning
hcodes
Hazard Classifications
Carc. 2
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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A Palumbo et al.
FEBS letters, 485(2-3), 109-112 (2000-11-30)
2-thiouracil (TU), an established antithyroid drug and melanoma-seeker, was found to selectively inhibit neuronal nitric oxide synthase (nNOS) in a competitive manner (K(i)=20 microM), being inactive on the other NOS isoforms. The drug apparently interfered with the substrate- and tetrahydrobiopterin
Silver colloid and film substrates in surface-enhanced Raman scattering for 2-thiouracil detection
Al-Shalalfeh MM, et al.
Royal Society of Chemistry Advances, 6, 75282-75292 (2016)
J Vanden Bussche et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 28(2), 166-172 (2011-01-26)
Thiouracil belongs to the xenobiotic thyreostats, which are growth-promoting agents illegally used in animal production. Recently it has been reported that thiouracil is suspected to have a natural origin. The European Union of Reference Laboratory guidance paper of 2007 acknowledged
Leslie Gay et al.
Genes & development, 27(1), 98-115 (2013-01-12)
Transcriptional profiling is a powerful approach for understanding development and disease. Current cell type-specific RNA purification methods have limitations, including cell dissociation trauma or inability to identify all RNA species. Here, we describe "mouse thiouracil (TU) tagging," a genetic and
Julie A L Kiebooms et al.
Journal of agricultural and food chemistry, 60(32), 7769-7776 (2012-07-28)
In recent years, the frequent detection of the banned substance thiouracil (TU) in livestock urine has been related to its endogenous formation following consumption of glucosinolate-rich Brassicaceae crops. Besides, TU residues have been recovered in these crops upon plant-derived myrosinase
Global Trade Item Number
| SKU | GTIN |
|---|---|
| T7750-100G | 04061837378560 |
| T7750-25G | 04061837378584 |
| T7750-1KG | 04061837378577 |
| T7750-250G | 04061833049983 |
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