T7450

T62

Name: T62
Brand: SIGMA

≥98% (HPLC), crystalline

Synonym(e):

2-Amino-3-(4-chlorobenzoyl)-5,6,7,8-tetrahydrobenzothiophene

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Über diesen Artikel

Empirische Formel (Hill-System):

C₁₅H₁₄ClNOS

CAS-Nummer:

40312-34-3

Molekulargewicht:

291.80

UNSPSC Code:

12352204

PubChem Substance ID:

24724635

MDL number:

MFCD02738687

Assay:

≥98% (HPLC)

Form:

crystalline

Quality level:

100

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Quality Level

100

assay

≥98% (HPLC)

form

crystalline

color

orange

solubility

DMSO: ~20 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

Nc1sc2CCCCc2c1C(=O)c3ccc(Cl)cc3

InChI

1S/C15H14ClNOS/c16-10-7-5-9(6-8-10)14(18)13-11-3-1-2-4-12(11)19-15(13)17/h5-8H,1-4,17H2

InChI key

OTZVBZFYMFTYKH-UHFFFAOYSA-N

Gene Information

human ... ADORA1(134)

Biochem/physiol Actions

Allosteric enhancer of A₁ adenosine receptor.

Studies in carrageenin-inflamed rats have reported that T62 can reverse thermal hypersensitivity[1]. T62 has also been reported to reduce mechanical allodynia and induce drug tolerance over time in rat models of neuropathic pain[2].

Preparation Note

T62 is soluble in DMSO at approximately 20 mg/ml and is insoluble in water.

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Analysenzertifikate (COA)

Lot/Batch Number

051M4770

124K4614

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Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism.

Xinhui Li et al.

The Journal of pharmacology and experimental therapeutics, 305(3), 950-955 (2003-02-28)

Activation of adenosine A1 receptors by endogenous adenosine or synthetic agonists produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain. Allosteric adenosine modulators facilitate and potentiate the action of adenosine

Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury.

Hideaki Obata et al.

Anesthesiology, 100(5), 1258-1262 (2004-04-29)

Intrathecal adenosine has antinociceptive effects under conditions of hypersensitivity. T62 (2-amino-3-(4-chlorobenzoyl)-5,6,7,8-tetrahydrobenzothiophen) is an allosteric adenosine receptor modulator that enhances adenosine binding to the A1 receptor. Intrathecal T62 reduces hypersensitivity to mechanical stimuli in a rat model of neuropathic pain by

Repeated dosing with oral allosteric modulator of adenosine A1 receptor produces tolerance in rats with neuropathic pain.

Xinhui Li et al.

Anesthesiology, 100(4), 956-961 (2004-04-17)

The positive allosteric adenosine receptor modulator, T62 (2-amino-3-(4-chlorobenzoyl)-5,6,7,8-tetrahydrobenzothiophene), has been shown to reduce mechanical allodynia in a rat model of neuropathic pain. However, whether chronic oral T62 retains efficacy in this pain model has not been examined. Therefore, the authors

Allosteric modulation of G protein-coupled receptors: perspectives and recent developments.

Willem Soudijn et al.

Drug discovery today, 9(17), 752-758 (2004-09-29)

Allosteric modulation of G protein-coupled receptors has recently been recognized as an alternative approach to gain selectivity in drug action. In this overview, allosteric modulators that enhance or diminish the effects of (endogenous) agonists or antagonists on a variety of

A Comparative Analysis of Methods for Quantitation of Sugars during the Corn-to-Ethanol Fermentation Process.

Sarah R Bilskey et al.

SLAS technology, 25(5), 494-504 (2020-03-01)

The quantitation of sugars, including glucose, the primary fermentable sugar; maltose (DP2); and maltotriose (DP3), is a standard procedure during the corn-to-ethanol fermentation process. The quantitation of glucose by the Megazyme Assay utilizing glucose oxidase and peroxidase enzymes (GOPOD) and

Global Trade Item Number

SKU	GTIN
T7450-5MG	04061832086248

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T62