T6568

Tyrphostin RG 13022

≥98%

• Synonym(e): 2-(3,4′-Dimethoxyphenyl)-1-(3″-pyridinyl)acrylonitrile
• Empirische Formel (Hill-System): C₁₆H₁₄N₂O₂
• CAS-Nummer: 136831-48-6
• Molekulargewicht: 266.29
• NACRES: NA.77
• PubChem Substance ID: 329826848
• UNSPSC Code: 12352200
• MDL number: MFCD00236444

Eigenschaften

• assay: ≥98%
• form: solid
• potency: IC₅₀ (3 micromolar for inhibition of EGF-receptor.)
• mp: 114-115 °C
• solubility: DMSO or ethanol: soluble
• storage temp.: 2-8°C
• SMILES string: COc1ccc(cc1OC)\C=C(\C#N)c2cccnc2
• InChI: 1S/C16H14N2O2/c1-19-15-6-5-12(9-16(15)20-2)8-14(10-17)13-4-3-7-18-11-13/h3-9,11H,1-2H3
• InChI key: DBGZNJVTHYFQJI-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Non-phenolic tyrphostin-class tyrosine kinase inhibitor.

Preparation Note

Tyrphostin RG 13022 is known to suppress EGF-induced cancer cell proliferation under in vitro conditions and can also inhibit the growth of tumors in nude mice.

Tyrphostin RG 13022 is soluble in DMSO and ethanol.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)