T2452

Talsaclidine

≥98% (HPLC), oil

• Synonym(e): (R)-3-(2-propynyloxy)-1-Azabicyclo[2.2.2]octane, WAL 2014
• Empirische Formel (Hill-System): C₁₀H₁₅NO
• CAS-Nummer: 147025-53-4
• Molekulargewicht: 165.23
• UNSPSC Code: 12352204
• PubChem Substance ID: 329826707
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: oil
• Quality level: 100

Eigenschaften

• SMILES string: C#CCO[C@H]1CN2CC[C@H]1CC2
• InChI: 1S/C10H15NO/c1-2-7-12-10-8-11-5-3-9(10)4-6-11/h1,9-10H,3-8H2/t10-/m0/s1
• InChI key: XVFJONKUSLSKSW-JTQLQIEISA-N
• assay: ≥98% (HPLC)
• form: oil
• solubility: DMSO: >5 mg/mL
• storage temp.: −20°C
• Quality Level: 100

Beschreibung

Biochem/physiol Actions

Talsaclidine aids in promoting the nonamyloidogenic α-secretase pathway in model systems.[1] It is more effective in stimulating muscarinic M 1 receptors than M 2 and M 3 receptors.[2] In anesthetized guinea pigs, talsaclidine has no bronchospastic effects, but it produces contracture in isolated tracheal muscle. Talsaclidine is considered a potential candidate for cholinergic replacement therapy.[3]

Talsaclidine is a M₁ selective muscarinic receptor agonist.

Talsaclidine is a M₁ selective muscarinic receptor agonist. Concentration-dependently, talsaclidine increases the release of APPs and dose-dependently. Talsaclidine decreases Aβ formation and decreases cerebrospinal fluid Aβ in AD patients.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Packaged under argon

Preparation Note

Talsaclidine is soluble in DMSO at a concentration that is greater than 5 mg/ml.

Sicherheitshinweise

• pictograms: GHS05
• signalword: Danger
• hcodes: H318
• pcodes: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves