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T2452

Sigma-Aldrich

Talsaclidine

≥98% (HPLC), oil

Synonym(e):

(R)-3-(2-propynyloxy)-1-Azabicyclo[2.2.2]octane, WAL 2014

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About This Item

Empirische Formel (Hill-System):
C10H15NO
CAS-Nummer:
147025-53-4
Molekulargewicht:
165.23
UNSPSC-Code:
12352204
PubChem Substanz-ID:
329826707
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

oil

Löslichkeit

DMSO: >5 mg/mL

Lagertemp.

−20°C

SMILES String

C#CCO[C@H]1CN2CC[C@H]1CC2

InChI

1S/C10H15NO/c1-2-7-12-10-8-11-5-3-9(10)4-6-11/h1,9-10H,3-8H2/t10-/m0/s1

InChIKey

XVFJONKUSLSKSW-JTQLQIEISA-N

Biochem./physiol. Wirkung

Talsaclidine aids in promoting the nonamyloidogenic α-secretase pathway in model systems. It is more effective in stimulating muscarinic M 1 receptors than M 2 and M 3 receptors. In anesthetized guinea pigs, talsaclidine has no bronchospastic effects, but it produces contracture in isolated tracheal muscle. Talsaclidine is considered a potential candidate for cholinergic replacement therapy.
Talsaclidine is a M1 selective muscarinic receptor agonist. Concentration-dependently, talsaclidine increases the release of APPs and dose-dependently. Talsaclidine decreases Aβ formation and decreases cerebrospinal fluid Aβ in AD patients.

Leistungsmerkmale und Vorteile

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Verpackung

Packaged under argon

Angaben zur Herstellung

Talsaclidine is soluble in DMSO at a concentration that is greater than 5 mg/ml.

Piktogramme

Corrosion
GHS05

Signalwort

Danger

H-Sätze

H318

Gefahreneinstufungen

Eye Dam. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

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M Wienrich et al.
Life sciences, 68(22-23), 2593-2600 (2001-06-08)
In functional pharmacological assays, talsaclidine has been described as a functionally preferential M1 agonist with full intrinsic activity, and less pronounced effects at M2- and M3 receptors. In accordance with this, cholinomimetic central activation measured in rabbits by EEG recordings
A Walland et al.
European journal of pharmacology, 330(2-3), 213-219 (1997-07-09)
The aim of the present investigation was to determine the reasons why the muscarinic receptor agonist talsaclidine (WAL 2014 FU, 1-azabicyclo[2.2.2] octane,3-(2-propynyloxy)-, (R)-,(E)-2-butenedioate) is devoid of bronchospastic effects in anaesthetized guinea pigs but causes contracture in isolated tracheal muscle from
C Hock et al.
Annals of the New York Academy of Sciences, 920, 285-291 (2001-02-24)
Brain amyloid load in Alzheimer's disease (AD) is, at least in genetic forms, associated with overproduction of amyloid beta-peptides (A beta). Thus, lowering A beta production is a central therapeutic target in AD and may be achieved by modulating such

Artikel

Muscarinic Acetylcholine Receptors

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

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