SRP8049
Periostin mouse
recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)
Synonym(e):
OSF-2, Osteoblast-specific factor 2, PC cell-derived growth factor
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10 μG
€ 340,00
€ 340,00
Versand in der Regel in 2 Wochen.
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10 μG
€ 340,00
About This Item
UNSPSC-Code:
12352200
NACRES:
NA.32
€ 340,00
Versand in der Regel in 2 Wochen.
Empfohlene Produkte
Biologische Quelle
mouse
Rekombinant
expressed in CHO cells
Markierung
FLAG® tagged
Assay
>95% (SDS-PAGE)
Form
lyophilized
Mol-Gew.
~85 kDa
Verpackung
pkg of 10 μg
Lagerbedingungen
avoid repeated freeze/thaw cycles
Verunreinigungen
<0.1 EU/μg endotoxin, tested
Farbe
white
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Lagertemp.
−20°C
Angaben zum Gen
mouse ... Postn(50706)
Allgemeine Beschreibung
Periostin (POSTN) is also called as osteoblast-specific factor 2.[1] It is a matricellular protein,[1] located in the alveolar walls.[1] This gene is located on human chromosome 13q13.[2]
Periostin was originally isolated as a osteoblast-specific factor that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Additionally, periostin expression has previously been shown to be significantly increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein (BMP-2). Abnormal expression of periostin is also linked to angiogenesis and metastasis in epithelial tumors.
Biochem./physiol. Wirkung
Periostin (POSTN) participates in collagen fibrillogenesis.[1] It plays a major role in the development of scar after traumatic spinal cord injury (SCI).[3] Periostin controls the activities of fibrocyte to stimulate myofibroblast differentiation and lung fibrosis.[1] It modulates the amount of collagen in tissue. Periostin also participates in the assembly of the extracellular matrix (ECM) architecture.[4]
Physikalische Form
Lyophilized from PBS.
Rekonstituierung
Reconstitute with 100 μL deionized water.
Sonstige Hinweise
Mouse periostin (aa 24-783) (isoform 5) is fused at the C-terminus to a FLAG®-tag.
Rechtliche Hinweise
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Kai-Wen Yu et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 117(4), 292-300 (2018-01-08)
Appropriate mechanical stress plays an important role in regulating the proliferation and differentiation of osteoblasts, whereas high-level mechanical stress may be harmful and compromise cell survival. Periostin, a matricellular protein, is essential in maintaining functional integrity of bone and collagen-rich
Periostin deficiency causes severe and lethal lung injury in mice with bleomycin administration.
Kondoh H, et al.
The Journal of Histochemistry and Cytochemistry, 64(7), 441-453 (2016)
Teresa Cobo et al.
PloS one, 11(1), e0147837-e0147837 (2016-01-26)
Periostin is an extracellular matrix protein highly expressed in collagen-rich tissues subjected to continuous mechanical stress. Functionally, periostin is involved in tissue remodeling and its altered function is associated to numerous pathological processes. In orthodontics, periostin plays key roles in
Shoichiro Ohta et al.
PloS one, 12(3), e0174547-e0174547 (2017-03-30)
The natural course of idiopathic pulmonary fibrosis (IPF) is variable. Predicting disease progression and survival in IPF is important for treatment. We previously demonstrated that serum periostin has the potential to be a prognostic biomarker for IPF. Our aim was
Periostin regulates fibrocyte function to promote myofibroblast differentiation and lung fibrosis.
Ashley SL, et al.
Mucosal Immunology, 10(2), 341?351-341?351 (2017)
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