SRP8044

CD40L, Soluble human

recombinant, expressed in CHO cells, FLAG^® tagged, >95% (SDS-PAGE)

• Synonym(e): ACRP30headless:CD154, ACRP30headless:CD40L, ACRP30headless:TNFSF5, ADIPOQ-CD40L
• NACRES: NA.77
• UNSPSC Code: 12352200
• Form: lyophilized
• Assay: >95% (SDS-PAGE)
• Biological source: human
• Recombinant: expressed in CHO cells
• Mol wt: 35-40 kDa by SDS-PAGE

Eigenschaften

• biological source: human
• recombinant: expressed in CHO cells
• tag: FLAG^® tagged
• assay: >95% (SDS-PAGE)
• form: lyophilized
• mol wt: 35-40 kDa by SDS-PAGE
• packaging: pkg of 10 μg
• storage condition: avoid repeated freeze/thaw cycles
• impurities: <0.01 EU/μg endotoxin, tested
• UniProt accession no.: P29965
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... CD40LG(959)

Beschreibung

General description

CD40L (cluster of differentiation 40 ligand) belongs to the tumor necrosis factor (TNF) family, and is expressed by basophils, B cells, monocytic cells, natural killer cells, platelets, mast cells and T cells. It is predominantly expressed on pro-inflammatory T cells. It also exists in a soluble form.

Biochem/physiol Actions

CD40L (cluster of differentiation 40 ligand) is active in its membrane-bound form. It interacts with CD40 and functions as a proinflammatory and procoagulant agent. The serum levels of soluble CD40L is elevated in malignant middle cerebral artery infarction (MMCAI) patients, especially in non-surviving patients.

Physical form

Lyophilized from PBS

Preparation Note

Reconstitute with 100 μL deionized water.

Other Notes

Human CD40L (aa 116-261) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG^®-tag.

Legal Information

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• Was ist los?: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable