SRP6006

IL-1RA murine

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

• Synonym(e): ICIL-1RA, IL-1ra3, IL1 inhibitor, IL1F3, IRAP
• NACRES: NA.32
• UNSPSC Code: 12352200
• Form: lyophilized
• Assay: ≥98% (SDS-PAGE)
• Biological source: mouse
• Recombinant: expressed in E. coli
• Mol wt: 17.4 kDa

Eigenschaften

• biological source: mouse
• recombinant: expressed in E. coli
• assay: ≥98% (SDS-PAGE)
• form: lyophilized
• mol wt: 17.4 kDa
• packaging: pkg of 50 μg
• technique(s): activity assay: suitable
• impurities: Endotoxin, tested
• NCBI accession no.: P25085
• UniProt accession no.: P25085
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: mouse ... IL-1RA(16181)

Beschreibung

General description

Research area: IMMUNO AND CKS

Interleukin-1 receptor antagonist (IL-1 RA) is a member of the interleukin 1 cytokine family. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL-1RA mouse recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17.4kDa. The IL1RA is purified by proprietary chromatographic techniques. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2.

Interleukin-1 RA is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL1 ra Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17.4kDa. The IL1RA is purified by proprietary chromatographic techniques.

Application

IL-1RA murine has been used as an antagonist to the interleukin-1 receptor in fibroblasts.

Biochem/physiol Actions

Interleukin-1 receptor antagonist (IL-1Ra) protein mediates the inhibition of interleukin 1-α (IL1A) and interleukin 1-β (IL1B) activities. It is also involved in the modulation of IL-1 related immune and inflammatory responses. A polymorphism in the IL-1Ra gene is reported to be associated with an increased risk of osteoporotic fractures and gastric cancer. IL-1Ra is effective in treating bronchopulmonary dysplasia in murine models.This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B) and modulates a variety of interleukin 1 related immune and inflammatory responses.

Physical form

Lyophilized from H?O containing NaHCO?

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in sterile ddH?O to a concentration ? 100 μg/ml. This solution can then be diluted into other aqueous buffers.

Other Notes

The IL1RA is purified by proprietary chromatographic techniques.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable