SRP4647

Galectin-7 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

• Synonym(e): Gal-7, Galactein 7, Galectin7, HKL-14, PI7, p53-induced gene 1 protein
• NACRES: NA.32
• UNSPSC Code: 12352202

Eigenschaften

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥98% (HPLC), ≥98% (SDS-PAGE)
• form: lyophilized
• mol wt: ~15.4 kDa
• packaging: pkg of 50 μg
• storage condition: avoid repeated freeze/thaw cycles
• impurities: endotoxin, tested
• NCBI accession no.: P47929
• UniProt accession no.: P47929
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... LGALS7(3963)

Beschreibung

General description

LGALS7 (galectin-7) is from the galectin family of β-galactoside-binding proteins. It is mainly present in the stratified epithelia, hair follicles and thymic Hassall′s corpuscles. The protein localizes in the nucleus and cytoplasm, and exists as a homodimer. Recombinant Human Galectin-7 is a 15.4kDa protein consisting of 136 amino acid residues

Biochem/physiol Actions

LGALS7 (galectin-7) helps in maintaining skin homeostasis, particularly after skin injury. It is also involved in keratinocyte proliferation and differentiation via JNK1 (c-Jun N-terminal kinase)-miR-203-p63 pathway. LGALS7 is a biomarker for skin condition and skin barrier disruption. In HeLa cells, it induces apoptosis most likely via JNK signaling. LGALS7 is downregulated in SV40-transformed cells and squamous cell carcinoma cells. Change in its activity/expression is associated with the progression of various epithelia-associated cancers. LGALS7 also helps in postmenstrual endometrial re-epithelialization.

Physical form

Sterile filtered and Lyophilized without additives.

Preparation Note

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.