SRP4633

VEGF-C human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

• Synonym(e): VEGFC, Vascular Endothelial Growth Factor-C
• UNSPSC Code: 12352202
• NACRES: NA.32
• MDL number: MFCD03458368

Eigenschaften

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥90% (SDS-PAGE)
• form: lyophilized
• mol wt: 15-16 kDa
• packaging: pkg of 10 μg
• storage condition: avoid repeated freeze/thaw cycles
• impurities: endotoxin, tested
• NCBI accession no.: Q6FH59
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... VEGFC(7424)

Beschreibung

General description

The recombinant VEGF-C (vascular endothelial growth factor-C) is a 125 amino acid protein that lacks the N-terminal signal peptide (from T103 to R227 of Gene Bank U58111). Human VEGF-C exhibits about 85% homology with mouse VEGF-C. The VEGFC gene is mapped to human chromosome 4q34.3.

Application

VEGF-C human has been used to determine cell proliferation and survival.

Biochem/physiol Actions

VEGF-C (vascular endothelial growth factor-C) promotes tumorigenesis, by inducing lymphatic metastasis. The production of VEGF-C is stimulated by pro-fibrotic transforming growth factor β. The main function of VEGF-C is to mediate lymphangiogenesis. Overexpression of VEGF-C in keratinocytes of skin causes dermal lymphatic vessel hyperplasia.

Physical form

Lyophilized without additives.

Preparation Note

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/mL.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable