SRP4121

IGF-I from rat

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

• Synonym(e): IGF-I, IGF1, IGFIA, Somatomedin C
• UNSPSC Code: 12352202
• NACRES: NA.32
• MDL number: MFCD00081716

Eigenschaften

• biological source: rat
• recombinant: expressed in E. coli
• assay: ≥95% (HPLC), ≥95% (SDS-PAGE)
• form: lyophilized
• mol wt: ~7.69 kDa
• packaging: pkg of 20 μg
• storage condition: avoid repeated freeze/thaw cycles
• impurities: endotoxin, tested
• NCBI accession no.: P08025
• UniProt accession no.: P08025
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: rat ... Igf1(24482)

Beschreibung

General description

IGF-I exists in two isoforms (IGF1A and IGF1B) in mouse due to alternative transcription.

IGF-I (insulin-like growth factor-I) is a member of a family of polypeptide growth factors. Rat IGF-I is a 7.69kDa protein containing 70 amino acid residues.

Application

IGF-I from rat has also been used to test its effect on the expression of its receptor in rheumatoid arthritis model.

IGF-I (Insulin-like Growth Factor-I) from rat has been used to study the the effect of IGF-I, IL-27 (interleukin-27) and IL-35 on the blood flow in the inflamed joints of rats.

Biochem/physiol Actions

IGF-I (Insulin-like growth factor-I) is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It mainly mediates growth and development. IGF-I is required for fetal growth and development. It is also involved in the growth and repair of heart tissues. IGF-I has been linked to neuroplasticity and hippocampal neurogenesis. It is important in the recovery from ischaemic injury.

IGF-I interacts with interleukins IL-27 and IL-35 and may play a role in chronic joint inflammation.

Physical form

Lyophilized without additives.

Preparation Note

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable