SRP3066

IGF-Binding Protein 7 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

• Synonym(e): PGI2-stimulating factor, PSF, Prostacyclin-stimulating factor, Tumor-derived adhesion factor (TAF), IBP-7, IGF binding protein related protein-1 (IGFBPrP1), Mac25
• NACRES: NA.32
• UNSPSC Code: 51111800
• Form: lyophilized
• Assay: ≥98% (HPLC), ≥98% (SDS-PAGE)
• Biological source: human
• Recombinant: expressed in E. coli
• Mol wt: 26.4 kDa

Eigenschaften

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥98% (HPLC), ≥98% (SDS-PAGE)
• form: lyophilized
• mol wt: 26.4 kDa
• packaging: pkg of 25 μg
• impurities: <0.1 EU/μg endotoxin, tested
• color: white to off-white
• UniProt accession no.: Q16270
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... IGFBP7(3490)

Beschreibung

General description

IGFBP7 (insulin-like growth factor-binding protein 7) is from the IGFBP superfamily and is widely expressed in tissues. It contains 11 cysteines, a heparin-binding site, a Kazal-type trypsin inhibitor domain and a carboxyl-terminal immunoglobulin-like type C repeat. The IGFBP7 gene is mapped to human chromosome 4q12.

Biochem/physiol Actions

IGFBP7 (insulin-like growth factor-binding protein 7) works as a tumor suppressor as well as an oncogene by controlling cell proliferation, cell attachment, apoptosis and angiogenesis. It is also involved in TGFβ (transforming growth factor β) signal pathway. IGFBP7 also interferes with the insulin pathway and is associated with the development of diabetes as well as cardiovascular diseases.IGFBP7 binds weakly to IGFs (insulin like growth factors) and strongly to insulin. It mainly participates in IGF-independent pathways.

Physical form

Lyophilized from 10 mM Sodium Phosphate, pH 6.8.

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Other Notes

MSSSDTCGPC EPASCPPLPP LGCLLGETRD ACGCCPMCAR GEGEPCGGGG AGRGYCAPGM ECVKSRKRRK GKAGAAAGGP GVSGVCVCKS RYPVCGSDGT TYPSGCQLRA ASQRAESRGE KAITQVSKGT CEQGPSIVTP PKDIWNVTGA QVYLSCEVIG IPTPVLIWNK VKRGHYGVQR TELLPGDRDN LAIQTRGGPE KHEVTGWVLV SPLSKEDAGE YECHASNSQG QASASAKITV VDALHEIPVK KGEGAEL

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable