SRP3015
Beta NGF human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Synonym(e):
beta-Nerve Growth Factor
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About This Item
UNSPSC-Code:
12352202
NACRES:
NA.32
Empfohlene Produkte
Biologische Quelle
human
Rekombinant
expressed in E. coli
Assay
≥98% (HPLC)
≥98% (SDS-PAGE)
Form
lyophilized
Wirksamkeit
<1.0 ng/mL ED50
Mol-Gew.
13.5 kDa
Verpackung
pkg of 20 μg
Methode(n)
cell culture | mammalian: suitable
Verunreinigungen
<0.1 EU/μg endotoxin, tested
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Lagertemp.
−20°C
Angaben zum Gen
human ... NGF(4803)
Allgemeine Beschreibung
β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human β-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (240 total amino acid residues). The three disulfide bonds are required for biological activity.
Anwendung
β NGF human has been used in immunohistochemistry.
Biochem./physiol. Wirkung
β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. The functional form of human b-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (240 total amino acid residues). The three disulfide bonds are required for biological activity.
Sequenz
SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA
Physikalische Form
Lyophilized with no additives.
Rekonstituierung
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
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European journal of histochemistry : EJH, 59(3), 2522-2522 (2015-10-03)
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The nerve growth factor 35 years later.
R Levi-Montalcini
Science (New York, N.Y.), 237(4819), 1154-1162 (1987-09-04)
Huiyu Chen et al.
Journal of inflammation (London, England), 16, 27-27 (2020-01-01)
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A Ullrich et al.
Nature, 303(5920), 821-825 (1983-06-30)
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