SRP2146

CAR, GST tagged, human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

• Synonym(e): CAR, CAR1, MB67, MGC150433, MGC97144, MGC97209
• NACRES: NA.26
• UNSPSC Code: 12352202
• Biological source: human
• Recombinant: expressed in E. coli
• Assay: ≥70% (SDS-PAGE)
• Form: frozen liquid
• Mol wt: ~66.3 kDa

Eigenschaften

• biological source: human
• recombinant: expressed in E. coli
• assay: ≥70% (SDS-PAGE)
• form: frozen liquid
• mol wt: ~66.3 kDa
• packaging: pkg of 10 μg
• storage condition: avoid repeated freeze/thaw cycles
• concentration: 350 μg/mL
• color: clear, colorless
• NCBI accession no.: NM_005122
• UniProt accession no.: Q14994
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... NR1I3(9970)

Beschreibung

Biochem/physiol Actions

The constitutive androstane receptor (CAR) was identified as a member of the orphan nuclear hormone receptor family in 1994. Although constitutively acitve, it can be further activated by ′phenobarbitol-like′ compounds, the most potent being the synthetic compound TCPOBOP. Upon activation, CAR regulates the xenobiotic drug metabolizing enzymes, cytochrome P450s. There are several overlapping functions between the nuclear receptors PXR and CAR. Recently, CAR, as well as PXR, have been shown to place a role in bile acid clearance and cholestatic liver injury.

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• Was ist los?: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable