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SRP2084

Sigma-Aldrich

VHL human

recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

Synonym(e):

HRCA1, RCA1, VHL1

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About This Item

UNSPSC-Code:
12352200
NACRES:
NA.26

Biologische Quelle

human

Rekombinant

expressed in insect cells

Assay

≥70% (SDS-PAGE)

Form

frozen liquid

Mol-Gew.

~26 kDa

Verpackung

pkg of 5 μg

Lagerbedingungen

avoid repeated freeze/thaw cycles

Konzentration

650 μg/mL

Farbe

clear colorless

NCBI-Hinterlegungsnummer

NM_000551

UniProt-Hinterlegungsnummer

P40337

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... VHL(7428)

Biochem./physiol. Wirkung

von Hippel-Lindau (VHL) disease is a hereditary cancer with a predilection for the central nervous system and retina. The von Hippel-Lindau tumor suppressor gene is mutated in families with von Hippel-Lindau disease and encodes a protein (VHL) of 213 amino acids with an acidic pentapeptide motif in the N-terminus. Mutations in the VHL gene result in constitutive expression of many hypoxia-induced genes, at least in part because of increases in the cellular level of hypoxia-inducible transcription factor HIF-1a. VHL protein binds to elongin B, elongin C, and Cul2 to form a stable complex that targets hypoxia inducible factors (HIFs) for degradation and transcriptional regulation. In addition, VHL protein has also been shown to interact with specific protein kinase C isoforms, histone deacetylases and HIF-1 inhibitor (HIF-1).

Physikalische Form

Clear and colorless frozen liquid solution

Angaben zur Herstellung

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Linehan, W.M., et al.
Journal of the American Medical Association, 273, 564-570 (1995)
A D Singh et al.
Survey of ophthalmology, 46(2), 117-142 (2001-10-02)
In recent years advances have been made in the clinical and genetic aspects of von Hippel-Lindau disease (VHL). Retinal capillary hemangioma is the most common manifestation of VHL disease and, therefore, ophthalmologists are frequently involved in the care of patients
F Latif et al.
Science (New York, N.Y.), 260(5112), 1317-1320 (1993-05-28)
A gene discovered by positional cloning has been identified as the von Hippel-Lindau (VHL) disease tumor suppressor gene. A restriction fragment encompassing the gene showed rearrangements in 28 of 221 VHL kindreds. Eighteen of these rearrangements were due to deletions
E Hasanov et al.
Oncogene, 36(24), 3450-3463 (2017-01-24)
The hypoxia-regulated tumor-suppressor von Hippel-Lindau (VHL) is an E3 ligase that recognizes its substrates as part of an oxygen-dependent prolyl hydroxylase (PHD) reaction, with hypoxia-inducible factor α (HIFα) being its most notable substrate. Here we report that VHL has an
Jung Jin Kim et al.
Genes & development, 29(21), 2244-2257 (2015-11-08)
The von Hippel-Lindau tumor suppressor pVHL is an E3 ligase that targets hypoxia-inducible factors (HIFs). Mutation of VHL results in HIF up-regulation and contributes to processes related to tumor progression such as invasion, metastasis, and angiogenesis. However, very little is

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