SRP2084

VHL human

recombinant, expressed in insect cells, ≥70% (SDS-PAGE)

• Synonym(e): HRCA1, RCA1, VHL1
• NACRES: NA.26
• UNSPSC Code: 12352200
• Form: frozen liquid
• Assay: ≥70% (SDS-PAGE)
• Biological source: human
• Recombinant: expressed in insect cells
• Mol wt: ~26 kDa

Eigenschaften

• biological source: human
• recombinant: expressed in insect cells
• assay: ≥70% (SDS-PAGE)
• form: frozen liquid
• mol wt: ~26 kDa
• packaging: pkg of 5 μg
• storage condition: avoid repeated freeze/thaw cycles
• concentration: 650 μg/mL
• color: clear colorless
• NCBI accession no.: NM_000551
• UniProt accession no.: P40337
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... VHL(7428)

Beschreibung

Biochem/physiol Actions

The von Hippel-Lindau tumor suppressor gene is mutated in families with von Hippel-Lindau disease and encodes a protein (VHL) of 213 amino acids with an acidic pentapeptide motif in the N-terminus. Mutations in the VHL gene result in constitutive expression of many hypoxia-induced genes, at least in part because of increases in the cellular level of hypoxia-inducible transcription factor HIF-1a.

von Hippel-Lindau (VHL) disease is a hereditary cancer with a predilection for the central nervous system and retina. The von Hippel-Lindau tumor suppressor gene is mutated in families with von Hippel-Lindau disease and encodes a protein (VHL) of 213 amino acids with an acidic pentapeptide motif in the N-terminus. Mutations in the VHL gene result in constitutive expression of many hypoxia-induced genes, at least in part because of increases in the cellular level of hypoxia-inducible transcription factor HIF-1a. VHL protein binds to elongin B, elongin C, and Cul2 to form a stable complex that targets hypoxia inducible factors (HIFs) for degradation and transcriptional regulation. In addition, VHL protein has also been shown to interact with specific protein kinase C isoforms, histone deacetylases and HIF-1 inhibitor (HIF-1).

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Sicherheitshinweise

• Lagerklasse: 10 - Combustible liquids
• Was ist los?: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable