SRP0310

HDAC6 H216A human

recombinant, expressed in baculovirus infected Sf9 cells, ≥75% (SDS-PAGE)

• Synonym(e): HD6, JM21, histone deacetylase 6
• UNSPSC-Code: 12352200
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human
• Rekombinant: expressed in baculovirus infected Sf9 cells
• Assay: ≥75% (SDS-PAGE)
• Form: aqueous solution
• Mol-Gew.: 161 kDa
• Verpackung: pkg of 50 μg
• Lagerbedingungen: avoid repeated freeze/thaw cycles
• Konzentration: 0.65 mg/mL
• NCBI-Hinterlegungsnummer: NM_006044
• UniProt-Hinterlegungsnummer: Q9UBN7
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• Angaben zum Gen: human ... HDAC6(10013)

Beschreibung

Allgemeine Beschreibung

HDAC6 (histone deacetylase 6) belongs to the HDAC family of proteins. HDACs are responsible for deacetylation of nuclear histone and nonhistone proteins, including transcription factors.[1] The mutation H216A results in catalytically inactive HDAC6.[2]
Human HDAC6 with H216A mutation (GenBank Accession No. NM_006044), full length with N-terminal GST tag, MW= 161kDa, expressed in a Baculovirus expression system.

Biochem./physiol. Wirkung

HDAC6 (histone deacetylase 6) is involved in the control of microtubules, growth factor-mediated chemotaxis, stress response in presence of misfolded protein and tumor invasion. It also participates in EGF (epidermal growth factor)-mediated β-catenin nuclear presence and activation of c-myc. In mouse model, HDAC6 is implicated in oncogene-induced tumorigenesis.[3] HDAC6 is the main deacetylase for α-tubulin and thus, is involved in cell motility.[4][5] It is also involved in the formation of SGs (stress granules) and SG proteins.[5] Mutations in the 3′-UTR of the HDAC6 gene suppresses hsa-miR-433-mediated post-transcriptional regulation. This results in overexpression of HDAC6, thereby causing X-linked chondrodysplasia.[6]

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable