SML4072

Tetrahydroberberine

≥98% (HPLC)

• Synonym(e): (±)-Canadine, (±)-Tetrahydroberberine, 5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-alpha]quinolizine, Canadine
• Empirische Formel (Hill-System): C₂₀H₂₁NO₄
• CAS-Nummer: 522-97-4
• Molekulargewicht: 339.39
• MDL-Nummer: MFCD00067284
• UNSPSC-Code: 12352200

Eigenschaften

• Biologische Quelle: (Corydalis yanhusuo)
• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear (Warmed)
• Lagertemp.: -10 to -25°C
• SMILES String: N21C(Cc5c(c(c(cc5)OC)OC)C2)c3c(cc4c(c3)OCO4)CC1
• InChIKey: VZTUIEROBZXUFA-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Dopamine receptor antagonist; nicotinic acetylcholine receptor (α4β2, α4β4, α7, α1β, 1γδ) modulator; induces clearance of low-density lipoprotein in mice.

Tetrahydroberberine (Canadine), an isoquinoline alkaloid isolated from corydalis tuber, is a potent dopamine D2 receptor antagonist (pKi = 6.08) and nicotinic acetylcholine receptor (α4β2, α4β4, α7, α1β, 1γδ) modulator. Tetrahydroberberine alleviates high-fat diet-induced hyperlipidemia and induces clearance of low-density lipoprotein and intermediate-density lipoprotein in mice.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable