SML3998

NVP-AUY922

≥98% (HPLC)

• Synonym(e): 5-(2,4-Dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide, 5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide, AUY922, Luminespib, VER 52296, VER-52296, VER52296
• Empirische Formel (Hill-System): C₂₆H₃₁N₃O₅
• CAS-Nummer: 747412-49-3
• Molekulargewicht: 465.54
• UNSPSC Code: 12352200
• MDL number: MFCD14635361
• NACRES: NA.21
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(C1=NOC(C2=C(O)C=C(O)C(C(C)C)=C2)=C1C3=CC=C(CN4CCOCC4)C=C3)NCC
• InChI: 1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,30-31H,4,9-12,15H2,1-3H3,(H,27,32)
• InChI key: NDAZATDQFDPQBD-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

High-affinity, potent and selective heat shock protein 90 (HSP90α/β) inhibitor with anti-cancer efficacy in cultures and in vivo.



NVP-AUY922 (Luminespib; VER-52296) is a high-affinity (HSP90β Kd = 1.7 nM), potent and selective heat shock protein 90 inhibitor (HSP90α/β Ki = 9.0/8.2 nM, HSP90α/β IC50 = 7.8/21 nM) that exhibits anti-proliferation potency in cancer cultures (GI50 from 2 to 40 nM among 29 cancer lines) and anti-tumor efficacy in vivo (50-75 mg/kg/day i.p.) by inducing cancer cells G1-G2 arrest and apoptosis.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable