SML3861

Methoxy-X04

≥98% (HPLC), Aβ fluorescent probe, powder

• Synonym(e): 4,4′-(1E,1′E)-2,2′-(2-Methoxy-1,4-phenylene)bis(ethene-2,1-diyl)diphenol, 4,4′-[(2-Methoxy-1,4-phenylene)di-(1E)-2,1-ethenediyl]bisphenol, MX04, MXO4, MeO-X04, MeO-XO4, MeX04, MeXO4, Methoxy-XO4, MethoxyX04, MethoxyXO4
• Empirische Formel (Hill-System): C₂₃H₂₀O₃
• CAS-Nummer: 863918-78-9
• Molekulargewicht: 344.40
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD25563254
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Produktname: Methoxy-X04, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: , Faint yellow to dark orange
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C

Beschreibung

Biochem/physiol Actions

A blood-brain barrier-permeant probe for live amyloid plaques imaging by fluorescent 2-photon microscopy.

Methoxy-X04 (MeO-X04, MethoxyX04, MeX04, MX04) is a blood-brain barrier-permeant fluorescent probe derived from the Chrysamine G and Congo red scaffold that retains affinity toward amyloid beta (Aβ) fibrils (Ki = 25.3 nM/Chrysamine G and 26.8 nM/Methoxy-X04), while being much more lipophilic than Chrysamine G and Congo red. Methoxy-X04 stains Aβ plaques, tangles, and cerebrovascular amyloid in postmortem brain sections with good specificity and is commonly utilized for high-resolution fluorescent imaging of individual amyloid plaques in live animals by 2-photon microscopy (Ex. 750-800 nm; Em. 380-480, 500-540, and 560-650 nm) following i.v. or i.p. injection (5-10 mg/kg).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable