SML3842

TAT-SAMβA trifluoroacetate

≥95% (HPLC)

• Synonym(e): SAMβA trifluoroacetate, TAT(47-57)-GG-βIIPKC(624-632) trifluoroacetate, TAT(47-57)-GG-SAMβA trifluoroacetate, YGRKKRRQRRR-GG-RNAENFDRF trifluoroacetate
• Empirische Formel (Hill-System): C₁₁₈H₁₉₅N₅₁O₃₁ · xC₂HF₃O₂
• Molekulargewicht: 2824.13 (free base basis)
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥95% (HPLC)
• Form: (Powder or Lyophilized powder or film)
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: (Powder or Lyophilized powder or film)
• storage condition: desiccated
• color: white to off-white
• storage temp.: -10 to -25°C

Beschreibung

Biochem/physiol Actions

Mitofusin 1 (MFN1)-βIIPKC association blocking peptide that prevents βIIPKC-mediated negative regulation of MFN1.

TAT-SAMβA is a mitofusin 1 (MFN1)-βIIPKC association blocking peptide that prevents βIIPKC-mediated negative regulation of MFN1. TAT-SAMβA protects neonatal and adult rat cardiac myocytes, but not Mfn1-knockout cells, from stress-induced death in cultures and improves cardiac contractility in rats with heart failure in vivo (3 mg/kg/day for 6 wks via Alzet pump delivery) by re-establishing mitochondrial morphology and function. TAT-SAMβA is composed of a 9-aa βIIPKC-derived MFN1-interacting sequence linked at the N-terminal to the cell permeable TAT(47-57) via a -Gly-Gly- spacer

Disclaimer

Hygroscopic

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable