SML3727

WIC1

≥98% (HPLC)

• Synonym(e): N-[4-(4-Ethyl-1-piperazinyl)phenyl]-2-oxo-2H-1-benzopyran-3-carboxamide, Wnt Inhibitor Compound 1
• Empirische Formel (Hill-System): C₂₂H₂₃N₃O₃
• CAS-Nummer: 943083-58-7
• Molekulargewicht: 377.44
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: yellow to brown
• solubility: DMSO:methanol (1:1): 2 mg/mL, clear (Warmed)
• storage temp.: -10 to -25°C
• SMILES string: O=C1OC2=C(C=C1C(NC3=CC=C(N4CCN(CC4)CC)C=C3)=O)C=CC=C2
• InChI key: YQXKWSNLAVFZJL-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Potent Wnt/β-catenin signaling inhibitor that reduces airway basal stem cell (ABSC) proliferation and induces ciliated cell differentiation.

WIC1 is a potent Wnt/β-catenin signaling inhibitor (IC50 = 10 nM against 24h 5 μM CHIR-induced BEAS2B TCF/LEF reporter activity) that reduces airway basal stem cell (ABSC) proliferation (92% reduction of 4d 2 μM CHIR-induced hABSC proliferation by 1 μM WIC1) and induces ciliated cell differentiation (by 1.9-fold on d14 with 100 nM WIC1; mABSCs under air-liquid interface (ALI) condition) by suppressing β-catenin Y489 phosphorylation (complete inhibition of 24h 5 μM CHIR-induced pY489 in BEAS2B by 1 μM WIC1) and TP63 expression (80% reduction of 9d 1 μM CHIR-induced TP63 in mABSC by 1 μM WIC1; 40% reduction of 48h 5 μM CHIR-induced TP63 in BEAS2B by 1 μM WIC1).

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable