SML3605

Selexipag

≥98% (HPLC)

• Synonym(e): 2-{4-[(5,6-Diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide, ACT-293987, NS-304
• Empirische Formel (Hill-System): C₂₆H₃₂N₄O₄S
• CAS-Nummer: 475086-01-2
• Molekulargewicht: 496.62
• UNSPSC Code: 51111800
• NACRES: NA.21
• MDL number: MFCD10567093
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: CC(C)N(CCCCOCC(NS(C)(=O)=O)=O)C1=NC(C2=CC=CC=C2)=C(C3=CC=CC=C3)N=C1
• InChI key: QXWZQTURMXZVHJ-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Potent, highly selective and orally available agonist for the PGI2 receptor (IP receptor); nonprostanoid IP receptor agonist

Selexipag is a potent, highly selective and orally available nonprostanoid agonist for the PGI2 receptor (IP receptor). Selexipag is readily hydrolyzed to the active metabolite ACT-333679 (MRE-269), which is also a potent and selective agonist at IP receptors. In contrast to the prostacyclin analogs iloprost and beraprost, selexipag and metabolite ACT-333679 does not contract gastric fundus up to mM concentrations.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable