SML3577

MMG-11

≥98% (HPLC)

• Synonym(e): Ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate, MMG 11, MMG11
• Empirische Formel (Hill-System): C₁₅H₁₄O₇
• CAS-Nummer: 313254-94-3
• Molekulargewicht: 306.27
• UNSPSC Code: 51111800
• NACRES: NA.77
• MDL number: MFCD00499091
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: , white to very dark gray
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(OCC)C1=CC=C(O1)CC(C2=CC=C(C(O)=C2O)O)=O
• InChI key: IIDUJWIVMGALOG-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

MMG-11 is a toll-like receptor 2 (TLR2) antagonist that selectively blocks TLR2/1 over TLR2/6 heterodimer-mediated sginaling in both human & murine species (NF-κB/AP-1 activation IC50 = 0.87 µM vs. 7.4 µM in hTLR2/1 or hTLR2/6 HEK293 reporter cells stimulated with 10 ng/mL TLR2/1 agonist Pam3CSK4 or 1 ng/mL TLR2/6 agonist Pam2CSK4; TNF/IL-6 secretion IC50 = 3.3/0.19 µM against 10 ng/mL Pam3CSK4 vs. 58/14 µM against 1 ng/mL Pam2CSK4 using murine macrophage RAW 264.7). In contrast, the TLR2 antagonist CU-CPT22 is selective for hTLR2/6 over hTLR2/1, while being weakly selective for mTLR2/1 over mTLR2/6 heterodimer.

Toll-like receptor 2 (TLR2) antagonist that selectively blocks TLR2/1 over TLR2/6 heterodimer-mediated sginaling in both human & murine species.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable