SML2588

JNJ0966

≥98% (HPLC)

• Synonym(e): N-[2-[(2-Methoxyphenyl)amino]-4′-methyl[4,5′-bithiazol]-2′-yl]acetamide
• Empirische Formel (Hill-System): C₁₆H₁₆N₄O₂S₂
• CAS-Nummer: 315705-75-0
• Molekulargewicht: 360.45
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD02045222
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [s]1c(nc(c1c2nc([s]c2)Nc3c(cccc3)OC)C)NC(=O)C
• InChI: 1S/C16H16N4O2S2/c1-9-14(24-16(17-9)18-10(2)21)12-8-23-15(20-12)19-11-6-4-5-7-13(11)22-3/h4-8H,1-3H3,(H,19,20)(H,17,18,21)
• InChI key: ZADCDCMLLGDCRM-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

JNJ0966 is a potent and highly selective inhibitor of matrix metalloproteinase-9 (MMP-9) zymogen activation. It appears that JNJ0966 binds to a structural pocket in proximity to the MMP-9 zymogen cleavage site near Arg-106. JNJ0966 reduces disease severity in in a mouse experimental autoimmune encephalomyelitis (EAE) model. JNJ0966 does not inhibit activation of MMP-2 zymogen, and has no effect on MMP-1, MMP-2, MMP-3, MMP-9 or MMP-14 catalytic activity.

potent and highly selective inhibitor of matrix metalloproteinase-9 (MMP-9) zymogen activation

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable