MS417, a (+)-JQ1 analog, is a potent inhibitor of bromodomain-containing protein 4 (BRD4) that is highly specific for BRD4-BD1 and BRD4-BD2. MS417 binds with similar affinity to BRD4-BD1 and BRD4-BD2 (Kd =36.1, and 25.4 nM), while bulky tBu of JQ1 prevents tight binding to the cavity at BD1.
potent broad spectrum BET (Bromodomain and Extra-Terminal domain) bromodomain inhibitor
A cell-permeable benzodiazepine compound that binds the tandem bromodomains of BET (bromodomain and extra terminal domain) family members BRD2 (1-473), BRD3 (1-434), and BRD4 (1-477) with high affinity.
assay
≥98% (HPLC)
assay
≥98% (HPLC)
assay
≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
form
powder
form
powder
form
solid
storage temp.
2-8°C
storage temp.
2-8°C
storage temp.
2-8°C
storage temp.
−20°C
solubility
DMSO: 2 mg/mL, clear
solubility
DMSO: 10 mg/mL (clear solution)
solubility
DMSO: 2 mg/mL, clear (warmed)
solubility
DMSO: 50 mg/mL
color
white to very dark brown
color
white to beige
color
white to light brown
color
yellow-white
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Lot/Batch Number
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