SML2379

Fluorizoline

≥98% (HPLC)

• Synonym(e): 2,5-bis(4-Chlorophenyl)-4,4,5-trifluoro-4,5-dihydrothiazole, 4,4,5-Trifluoro-2,5-bis(4-chlorophenyl)-4,5-dihydrothiazole
• Empirische Formel (Hill-System): C₁₅H₈Cl₂F₃NS
• CAS-Nummer: 1362243-70-6
• Molekulargewicht: 362.20
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: ClC(C=C1)=CC=C1C2=NC(F)(F)C(C3=CC=C(Cl)C=C3)(F)S2
• InChI key: JGDLZQYCDVDWNE-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

Fluorizoline is a prohibitin (PHB) 1/2-binding diaryl trifluorothiazoline compound that induces p53-independent apoptosis in various cancer cultures (IC50 from 1.6 μM/Bx-PC3 to 9.4 μM/JeKo 1; 24 h) and upregulates proapoptotic Noxa and Bim mRNAs in wild-type, but not PHBs-depleted MEFs. Box(-/-)/Bak(-/-) or Noxa(-/-)/Bim(-/-) MEFs as well as BAX/BAK- or NOXA-downregulated HeLa cells are resistant to fluorizoline-induced apoptosis. Fluorizoline treatment is shown to prevent active RAS-CRAF interaction and downstream MEK1/2 activation following EGF stimulation in HeLa cells (10 μM).

Prohibitin (PHB) 1/2-binding diaryl trifluorothiazoline that induces p53-independent apoptosis.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable