SML2187

RL5a

≥98% (HPLC)

• Synonym(e): N2-[2-(2-Furanyl)-4-quinolinyl]-N1,N1-dimethyl-1,2-ethanediamine
• Empirische Formel (Hill-System): C₁₇H₁₉N₃O
• CAS-Nummer: 133671-66-6
• Molekulargewicht: 281.35
• MDL-Nummer: MFCD00929354
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to very dark brown
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• InChI: 1S/C17H19N3O/c1-20(2)10-9-18-15-12-16(17-8-5-11-21-17)19-14-7-4-3-6-13(14)15/h3-8,11-12H,9-10H2,1-2H3,(H,18,19)
• InChIKey: CRGKLHXVNVZAPA-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

RL5a is a potent inhibitor of the replication licensing system in human cells. RL5a blocks the binding of the origin recognition complex (ORC) to origin DNA, which is required interaction for licensing. RL5a appears to act as noncompetitive inhibitor of ORC with respect to ATP.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3