This product has not been tested suitability in cell culture and endotoxin has not been determined. Currently, an endotoxin and cell culture tested product option is not available. Note that this product has been used successfully in cell culture by other researchers. Please see the link below to review a related article:
https://www.nature.com/articles/s41564-020-0701-5
Fortfahren mit
SML2042
27-hydroxycholesterol
≥98% (HPLC), LXR agonist, powder
Synonym(e):
(25R)-26-Hydroxycholesterol, (25R)-Cholest-5-ene-3b,26-diol, 25(R)-27-hydroxy Cholesterol, 27-OHC
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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
5 mg | Warenkorb auf Verfügbarkeit prüfen | € 166,00 |
25 mg | Warenkorb auf Verfügbarkeit prüfen | € 664,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
C27H46O2
CAS-Nummer:
Molekulargewicht:
402.65
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Technischer Dienst
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Unterstützung erhaltenProduktname
27-hydroxycholesterol, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -25 to -35°, c = 0.5 in chloroform-d
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
−20°C
SMILES string
O[C@H]1CC[C@@]2([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CCC[C@H](CO)C)C)(CC3)C)CC=C2C1)C
InChI
1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18-,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChI key
FYHRJWMENCALJY-YSQMORBQSA-N
General description
27-hydroxycholesterol induces glutathione depletion, apoptosis, reactive oxygen species (ROS) generation and inflammation.
Biochem/physiol Actions
27-hydroxycholesterol is a peripherally derived oxysterol that that is produced by the enzyme CYP27A1. There has beeen increasing interest in the oxysterols, especially in the brain. Impairment of brain cholesterol metabolism has been associated with several neurodegenerative diseases. 27-hydroxycholesterol crosses the blood brain barrier and have been associated with Alzheimer′s disease. It is an activator of LXRα and LXRβ in vitro with EC50 values of 85 and 71 nM and an inhibitor of cholesterol synthesis. 27-hydroxycholesterol has also been shown to bind to estrogen receptor-α (ERα) and Erβ, acting as an endogenous selective estrogen receptor modulator (SERM). In murine models of breast cancer 27-hydroxycholesterol significantly increased tumor growth and metastasis.
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Dieser Artikel | |||
|---|---|---|---|
| description ≥98% (HPLC) | description Avanti Research™ - A Croda Brand | description Avanti Research™ - A Croda Brand | description ≥98% |
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay >99% (TLC) | assay >99% (TLC) | assay ≥98% |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. room temp |
| solubility DMSO: 2 mg/mL, clear (warmed) | solubility - | solubility - | solubility - |
| color white to beige | color - | color - | color - |
| optical activity [α]/D -25 to -35°, c = 0.5 in chloroform-d | optical activity - | optical activity - | optical activity - |
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Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Is this culture grade and endotoxin tested? thanks.
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