SML2031

S4

≥98% (HPLC)

• Synonym(e): 4-(3′-(3″,5″-Dimethylphenyl)ureido)phenyl sulfamate, 4-[(3,5-Dimethylphenyl)ureido]phenyl sulfamate, 4-[[[(3,5-Dimethylphenyl)amino]carbonyl]amino]phenyl sulfamic acid ester
• Empirische Formel (Hill-System): C₁₅H₁₇N₃O₄S
• CAS-Nummer: 1330061-67-0
• Molekulargewicht: 335.38
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD30182321
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: O=S(OC1=CC=C(NC(NC2=CC(C)=CC(C)=C2)=O)C=C1)(N)=O
• InChI key: HGVHSNXRZYOTPD-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

S4 is a potent and selective inhibitor against sulfamate carbonic anhydrase (CA) subtypes CAIX & CAXII (Ki = 2, 7, 546, 5600 nM against human CA XII, IX, II, and I, respectively). S4 selectively inhibits migration upon anoxia/hypoxia-induced CAIX expression in cancer cultures (% inhibition/conc./cell line = 54%/100 μM/WRO, 65%/33 μM/MDA-MB-231), while exhibiting no inhibitory effects under normoxia or among non-CAIX-expressing cells (HCT116 & RT112). Daily intraperitoneal injection (10 mg/kg) is reported to reduce the metastatic tumor burden in lungs of mice bearing orthotopic eGFP-MDA-MB-231 tumors in vivo.

Sulfamate carbonic anhydrase IX & XII (CAIX & CAXII) inhibitor

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable