SML1556

AEM1

≥98% (HPLC)

• Synonym(e): ARE expression modulator 1, N-(1,3-Benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-thieno[2,3-d]pyrimidin-4-amine
• Empirische Formel (Hill-System): C₂₀H₁₄FN₃O₂S
• CAS-Nummer: 1030123-90-0
• Molekulargewicht: 379.41
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to light brown
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: Fc1ccc(cc1)c2c3c([s]c2)[nH]cn[c]3=NCc4cc5c(cc4)OCO5
• InChI: 1S/C20H14FN3O2S/c21-14-4-2-13(3-5-14)15-9-27-20-18(15)19(23-10-24-20)22-8-12-1-6-16-17(7-12)26-11-25-16/h1-7,9-10H,8,11H2,(H,22,23,24)
• InChI key: QGYLTGSHWIGJJD-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

AEM1 is a potent inhibitor of deregulated Nrf2 transcriptional activity.

AEM1 is a potent inhibitor of deregulated Nrf2 transcriptional activity. AEM1 broadly decreases the expression of NRF2 controlled genes and sensitizes A549 cells to various chemotherapeutic agents.

AEM1 (ARE expression modulator 1) is also a selective inhibitor of sirtuin 2, which is a protein deacetylase mediated by NAD⁺.[1] Sirtuin 2 supports tumor cell proliferation, thus its inhibition stimulates cell death in tumors.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable