SML1509

MK6-83

≥98% (HPLC)

• Synonym(e): 5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide
• Empirische Formel (Hill-System): C₁₆H₂₀N₂O₂S₂
• CAS-Nummer: 1062271-24-2
• Molekulargewicht: 336.47
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to brown
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: [S](=O)(=O)(Nc2c(cccc2)N3CCCCC3)c1[s]c(cc1)C
• InChI: 1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,17H,2,5-6,11-12H2,1H3
• InChI key: IRGYSXZCDAWOOC-UHFFFAOYSA-N

Beschreibung

Biochem/physiol Actions

MK6-83 is a potent activator of wild type and mutant variants F465L and F408D of TRPML1 channel.

MK6-83 is a potent activator of wild type and mutant variants F465L and F408D of TRPML1 channel. MK6-83 weakly activates TRPML mutants R403C or V446L. MK6-83 restores channel function and rescue disease associated abnormalities in mucolipidosis type IV (MLIV) patient cells.

MK6-83 is known to stimulate caspase-3-dependent apoptosis. It can also decrease the viability of cells.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable