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SML1368

Sigma-Aldrich

CLP257

≥98% (HPLC)

Synonym(e):

(5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone

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About This Item

Empirische Formel (Hill-System):
C14H14FN3O2S
CAS-Nummer:
1181081-71-9
Molekulargewicht:
307.34
MDL-Nummer:
MFCD28166488
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329825822
NACRES:
NA.77

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

, white to yellow to light brown

Löslichkeit

DMSO: 20 mg/mL, clear

Lagertemp.

2-8°C

SMILES String

O=C1/C(SC(N2CCCCN2)=N1)=C/C3=CC=C(F)C=C3O

InChI

1S/C14H14FN3O2S/c15-10-4-3-9(11(19)8-10)7-12-13(20)17-14(21-12)18-6-2-1-5-16-18/h3-4,7-8,16,19H,1-2,5-6H2/b12-7-

InChIKey

SKCADXVKQRCWTR-GHXNOFRVSA-N

Anwendung

CLP257 has been used as a K+- Cl- cotransporter 2 (KCC2) enhancer in human neuron culture.

Biochem./physiol. Wirkung

CLP257 is a selective K+-Cl− cotransporter KCC2 activator that restored impaired Cl− transport in neurons with reduced KCC2 activity. Apparently, CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally.
In streptozotocin treated rats, by activating a K+- Cl- cotransporter 2 (KCC2) in the arginine-vasopressin neuron, CLP257 mediates γ-aminobutyric acid (GABA)ergic excitation. It is however inactive with KCC1, KCC3 and KCC4.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Young-Beom Kim et al.
Diabetes, 67(3), 486-495 (2017-12-08)
Diabetes mellitus (DM) is associated with increased plasma levels of arginine-vasopressin (AVP), which may aggravate hyperglycemia and nephropathy. However, the mechanisms by which DM may cause the increased AVP levels are not known. Electrophysiological recordings in supraoptic nucleus (SON) slices
Aaron J Barbour et al.
Neurobiology of disease, 141, 104878-104878 (2020-04-29)
Approximately half of people infected with HIV (PWH) exhibit HIV-associated neuropathology (neuroHIV), even when receiving combined antiretroviral therapy. Opiate use is widespread in PWH and exacerbates neuroHIV. While neurons themselves are not infected, they incur sublethal damage and GABAergic disruption
Martin Gagnon et al.
Nature medicine, 19(11), 1524-1528 (2013-10-08)
The K(+)-Cl(-) cotransporter KCC2 is responsible for maintaining low Cl(-) concentration in neurons of the central nervous system (CNS), which is essential for postsynaptic inhibition through GABA(A) and glycine receptors. Although no CNS disorders have been associated with KCC2 mutations

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