SML1234

HAMNO

≥98% (HPLC)

• Synonym(e): (1Z)-1-[(2-Hydroxyanilino)methylidene]naphthalen-2-one, 1-[[(2-Hydroxyphenyl)imino]methyl]-2-naphthalenol, CID 6335338, MLS000737724, NS C111847, NSC111847
• Empirische Formel (Hill-System): C₁₇H₁₃NO₂
• CAS-Nummer: 138736-73-9
• Molekulargewicht: 263.29
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: yellow to orange
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: N(c3c(cccc3)O)\C=C1\c2c(cccc2)C=CC\1=O
• InChI key: NADCEWZYITXLKJ-KAMYIIQDSA-N

Beschreibung

Biochem/physiol Actions

HAMNO is a potent and selective inhibitor of replication protein A (RPA) interactions with proteins involved in the replication stress response. HAMNO binds the N-terminal domain of RPA70 and inhibits both ATR autophosphorylation and phosphorylation of RPA32 Ser33 by ATR. HAMNO enhances DNA replication stress in cancer cells and slow tumor growth in vivo.

HAMNO is a potent and selective inhibitor of replication protein A (RPA) interactions.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable