SML0681

Febrifugine dihydrochloride

≥95% (HPLC)

• Synonym(e): 3-[3-[(2R,3S)-3-Hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone dihydrochloride
• Empirische Formel (Hill-System): C₁₆H₁₉N₃O₃ · 2HCl
• CAS-Nummer: 32434-42-7
• Molekulargewicht: 374.26
• UNSPSC Code: 51111800
• PubChem Substance ID: 329825583
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• optical activity: [α]/D 10 to 15°, c = 1 in H₂O
• storage condition: desiccated
• color: off-white to gray-brown
• solubility: H₂O: 15 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O=C1C2=CC=CC=C2N=CN1CC(C[C@@H]3[C@@H](O)CCCC3)=O.C
• InChI: 1S/C17H20N2O3.CH4/c20-13(9-12-5-1-4-8-16(12)21)10-19-11-18-15-7-3-2-6-14(15)17(19)22;/h2-3,6-7,11-12,16,21H,1,4-5,8-10H2;1H4/t12-,16+;/m1./s1
• InChI key: SNTOTCUGCWLHEZ-KKJWGQAZSA-N

Beschreibung

Biochem/physiol Actions

Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan. Recent studies indicate that its mechanism of action is as an inhibitor of prolyl-transfer RNA synthetase (ProRS).

Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan; inhibitor of prolyl-transfer RNA synthetase (ProRS).

Febrifugine dihydrochloride exhibits strong antimalarial activity against Plasmodium falciparum, the most insidious malaria causative agent. The adverse effects of febrifugine include diarrhoea, vomiting and liver toxicity.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable